Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate

Epilepsy & Behavior : E&B
Neveen A NoorYasser A Khadrawy

Abstract

The present study aimed to investigate the effect of curcumin and Nigella sativa oil (NSO) on amino acid neurotransmitter alterations and the histological changes induced by pilocarpine in the hippocampus and cortex of rats. Epilepsy was induced by i.p. injection of pilocarpine, and the animals were left for 22 days to establish spontaneous recurrent seizures. They were then treated with curcumin, NSO or valproate for 21 days. Pilocarpine induced a significant increase in hippocampal aspartate and a significant decrease in glycine and taurine levels. In the cortex, a significant increase in aspartate, glutamate, GABA, glycine, and taurine levels was obtained after pilocarpine injection. Treatment of pilocarpinized rats with curcumin and valproate ameliorated most of the changes in amino acid concentrations and reduced the histopathological abnormalities induced by pilocarpine. N. sativa oil failed to improve the pilocarpine-induced abnormalities. This may explain the antiepileptic effect of curcumin and suggest its use as an anticonvulsant.

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Citations

Jul 5, 2015·Epilepsy & Behavior : E&B·Sitaram Jaideep SriranjiniVernekar Sanjeeva Mamta
Sep 6, 2013·Pharmaceutical Biology·Zahra KiasalariTourandokht Baluchnejadmojarad
May 7, 2013·Asian Pacific Journal of Tropical Biomedicine·Aftab AhmadFiroz Anwar
Jan 6, 2017·Human Molecular Genetics·Nasir MirzaAnthony G Marson
Mar 9, 2019·Metabolic Brain Disease·Ibraheem HusainAbul Kalam Najmi
Nov 26, 2015·Journal of Toxicology·Mohammad Reza Khazdair
Jan 21, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Barış AkgülMutay Aslan
Aug 20, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Swati HalderAbhijit Dey

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