PMID: 11909753Mar 23, 2002Paper

Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay

Mutation Research
Alok DhawanCostas Ioannides

Abstract

The polyphenolic dimers, epicatechin-4beta-8-catechin (B1), epicatechin-4beta-8-epicatechin (B2), catechin-4beta-8-catechin (B3), catechin-4beta-8-epicatechin (B4), and the gallate ester epicatechin-4beta-8-epicatechin gallate (B'2G) were isolated from grape seeds, and theaflavins and theafulvins from black tea brews. The ability of these naturally-occurring polyphenols to afford protection against the genotoxicity of the heterocyclic amine 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) was compared with that of the monomeric tea flavanols, (+)-catechin (C), (-)-epicatechin (EC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG). Genotoxic activity was evaluated in human peripheral lymphocytes using the Comet assay. At the concentration range of 1-100 microM, neither the monomeric nor the dimeric flavanols prevented the lymphocyte DNA damage induced by Trp-P-2. In contrast, both of the black tea polyphenols, theafulvins and theaflavins, at a dose range of 0.1-0.5 mg/ml, prevented, in a concentration-dependent manner, the DNA damage elicited by Trp-P-2. Finally, neither the monomeric and dimeric polyphenols (100 microM) nor the theafulvins and theaflavins (0.5mg/ml) caused any D...Continue Reading

References

Jul 1, 1991·Carcinogenesis·E E DeschnerH L Newmark
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Apr 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B L Pool-ZobelP Schmezer
Jan 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Bu-AbbasR Walker
Feb 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·O S SohnJ H Weisburger
Jun 1, 1997·Environmental Health Perspectives·C S YangG Y Yang
Jan 1, 1997·Teratogenesis, Carcinogenesis, and Mutagenesis·D AndersonT W Yu
Feb 3, 1998·Critical Reviews in Food Science and Nutrition·P C HollmanC S Yang
Sep 12, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Bu-AbbasC Ioannides
Jan 8, 1999·Mutation Research·Y Kuroda, Y Hara
Mar 29, 2000·Environmental and Molecular Mutagenesis·R R TiceY F Sasaki
Apr 7, 2000·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M N CliffordL A Mitchell
Nov 23, 2000·Journal of Agricultural and Food Chemistry·S de Pascual-TeresaJ C Rivas-Gonzalo
Mar 1, 1999·Environmental Toxicology and Pharmacology·A Bu-AbbasC Ioannides

❮ Previous
Next ❯

Citations

Apr 23, 2008·Cell Biology and Toxicology·Alok DhawanDevendra Parmar
May 19, 2005·Plant Foods for Human Nutrition·R BunkovaM Nemec
Mar 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·P Vitaglione, V Fogliano
Jun 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hildegard M SchullerR Schmoyer
Aug 2, 2003·Archives of Biochemistry and Biophysics·D ErbaG Testolin
Jan 29, 2014·Biological Trace Element Research·Kumar Suranjit Prasad, Kaliaperumal Selvaraj
Apr 24, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Fahad AliYasir Hasan Siddique
Jul 25, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M E DelgadoP Morales
Sep 29, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Glei, B L Pool-Zobel
Sep 8, 2012·Food Chemistry·Ghada Ben RhoumaLeila Chekir-Ghedira
Dec 3, 2014·Research in Veterinary Science·Rong H YinXiao R Han
Dec 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kausar M AnsariMukul Das
Feb 1, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mengyao ZhaoFang Chen
Aug 23, 2005·Environmental and Molecular Mutagenesis·Hifzur R SiddiqueD Kar Chowdhuri
Oct 11, 2017·Toxicology and Industrial Health·Vinaya ShettyR C Chaubey
May 10, 2005·International Journal of Cancer. Journal International Du Cancer·Chris I R GillIan Rowland
Dec 14, 2006·Environmental and Molecular Mutagenesis·Adekunle A BakareAlok Dhawan
Dec 21, 2005·Carcinogenesis·Kristin L LockettJennifer J Hu
Mar 2, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Leonilla ElblingMichael Micksche
Feb 21, 2013·Human & Experimental Toxicology·G B RhoumaL Chékir-Ghédira
Apr 28, 2019·International Journal of Molecular Sciences·Alicja M NogackaSonia González
Oct 15, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Costas Ioannides, Victoria Yoxall
Sep 2, 2008·Biological & Pharmaceutical Bulletin·Vesna BenkovićNada Orolić

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.