Evaluation of the antihyperlipidemic properties of dietary supplements

Pharmacotherapy
M F Caron, C M White

Abstract

We reviewed the published literature regarding the antihyperlipidemic effects of dietary supplements. A search of MEDLINE database, EMBASE Drugs and Pharmacology database, and the Internet was performed, and pertinent studies were identified and evaluated. References from published articles and tertiary references were used to gather additional data. Published trials indicate that red yeast rice, tocotrienols, gugulipid, garlic, and soy protein all have antihypercholesterolemic effects. These supplements, as well as omega-3 fatty acids, also have antihypertriglyceridemic effects. In clinical trials none of the agents led to a reduction in low-density lipoproteins greater than 25%, suggesting modest efficacy. When recommending these supplements, clinicians should keep in mind that their long-term safety is not established and patients should be monitored closely.

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Citations

Apr 9, 2004·Life Sciences·Mélanie Journoud, Peter J H Jones
Jan 30, 2003·American Journal of Preventive Medicine·Jessie Satia-AboutaEmily White
Jun 20, 2002·Journal of Midwifery & Women's Health·Pamela S Stewart Fahs, Mary Ann Faucher
Feb 28, 2013·Expert Opinion on Biological Therapy·Giuseppe DerosaPamela Maffioli
May 27, 2011·Journal of Clinical Lipidology·Matthew K ItoUNKNOWN National Lipid Association Expert Panel on Familial Hypercholesterolemia
Jul 11, 2008·Mayo Clinic Proceedings·David J BeckerNayyar Iqbal
Aug 30, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marianna MazzaSalvatore Mazza
Feb 24, 2009·Journal of Pharmaceutical and Biomedical Analysis·Francisco J RuperezCoral Barbas
May 1, 2015·Expert Review of Endocrinology & Metabolism·Giuseppe Derosa, Pamela Maffioli
May 20, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kelly M Shields, Michael P Moranville
Feb 18, 2006·The Journal of Nutrition·David J GreenblattLisa L von Moltke
Jul 10, 2003·Journal of Agricultural and Food Chemistry·Li-Chen WuChung-Shi Yang

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