Evaluation of the antihypertensive effect of barnidipine, a dihydropyridine calcium entry blocker, as determined by the ambulatory blood pressure level averaged for 24 h, daytime, and nighttime. Barnidipine Study Group

American Journal of Hypertension
Y ImaiK Yoshinaga

Abstract

We evaluated the effect of barnidipine, a dihydropyridine calcium antagonist, administered once daily in the morning in a dose of 5, 10, or 15 mg on ambulatory blood pressure (BP) in 34 patients (51.3+/-9.6 years). Hypertension was diagnosed based on the clinic BP. The patients were classified into groups according to the ambulatory BP: group 1, dippers with true hypertension; group 2, nondippers with true hypertension; group 3, dippers with false hypertension; and Group 4, nondippers with false hypertension. Barnidipine reduced the clinic systolic BP (SBP) and diastolic BP (DBP) in all groups and significantly reduced the average 24 h ambulatory BP (133.0+/-16.5/90.7+/-12.3 mm Hg v 119.7+/-13.7/81.8+/-10.3 mm Hg, P < .0001 for both SBP and DBP). Barnidipine significantly reduced the daytime ambulatory SBP in groups 1, 2, and 3, but not in group 4, and significantly reduced daytime ambulatory DBP in group 1 but not in groups 2, 3, and 4. Barnidipine significantly reduced the nighttime ambulatory SBP only in group 2 and the nighttime ambulatory DBP in groups 2 and 4. Once-a-day administration of barnidipine influenced 24 h BP on true hypertensives (the ratio of the trough to peak effect > 50%), but had minimal effect on low BP s...Continue Reading

Citations

Aug 10, 2001·Current Opinion in Nephrology and Hypertension·T G Pickering, K Kario
Sep 23, 2006·The Journal of International Medical Research·W ZhuM Yamamoto
Aug 22, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Hye-Mi KimKi-Ho Cho
Aug 9, 2002·The Journal of International Medical Research·C S LiauT M Lee
Jan 11, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Jan 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhi-Gang ChengGuang-Ya Xiang
Jul 28, 1999·Clinical and Experimental Hypertension : CHE·Y ImaiS Hisamichi
Apr 15, 2004·The Journal of International Medical Research·P BuranakitjaroenC Chawantanpipat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.