Evaluation of the antinociceptive and anti-inflammatory activities of piperic acid: Involvement of the cholinergic and vanilloid systems

European Journal of Pharmacology
Poliana de Araujo OliveiraBruno G Marinho

Abstract

Piperin is the active compound of black pepper (Piper nigrum). From the piperine was obtained the molecule of the piperic acid (PAC). The objective of this study was to evaluate the antinociceptive and anti-inflammatory of the compound. The antinociceptive effects of PAC were evaluated by abdominal writhing, formalin, capsaicin and tail-flick tests; while the anti-inflammatory effects were evaluated by paw oedema and air pouch tests, and in vitro COX inhibition assay. The possible action mechanism of PAC was evaluated using naloxone, L-NAME, glibenclamide and atropine in tail flick test and by Cholinesterase activity assay and production of TNF-α and IL-1β. PAC significantly reduced the nociceptive effects induced by acetic acid or formalin in mice. PAC also demonstrated an antinociceptive effect in the tail-flick model. The muscarinic receptor antagonist, atropine reduced the antinociceptive effect of PAC in the tail-flick model. PAC was able to inhibit capsaicin-induced nociception, showing involvement of TRPV1. The compound did not alter the motor capacity of the animals, not interfering in the nociceptive response. PAC also showed anti- inflammatory activity by inhibiting the formation of carrageenan-induced paw oedema, leu...Continue Reading

References

Feb 26, 1998·Pharmacology, Biochemistry, and Behavior·T SakuradaK Kisara
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Apr 12, 2007·International Anesthesiology Clinics·Jun-Ming Zhang, Jianxiong An
Apr 28, 2007·Nature Reviews. Drug Discovery·Arpad SzallasiSamer R Eid
Feb 2, 2008·Biological & Pharmaceutical Bulletin·Luiz Gustavo FischerMárcia Maria de Souza
Mar 19, 2008·Transplant Immunology·Silvana Virginia Gagliotti VigilTânia Silvia Fröde
Sep 26, 2009·Current Molecular Pharmacology·May Hamza, Raymond A Dionne
Dec 26, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Pennapa ChonpathompikunlertSupaporn Muchimapura
May 13, 2010·Bioscience, Biotechnology, and Biochemistry·Yukiko OkumuraTatsuo Watanabe
May 13, 2011·Behavioural Pharmacology·Bruno Guimarães MarinhoPatricia D Fernandes
Sep 17, 2011·Science·Mauricio Rosas-BallinaKevin J Tracey
Jan 12, 2012·British Journal of Pharmacology·E S FernandesJ E Keeble
Dec 3, 2013·Pain·Michael FischerPeter Reeh
Oct 9, 2014·Planta medica·Gabriela Carmelinda Martins Dos SantosBruno Guimarães Marinho
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Farhana TasleemZafar Alam Mahmood
Nov 26, 2015·Journal of Nutritional Science and Vitaminology·Tatsuo Watanabe, Yuko Terada
Apr 12, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Amy Ho Yan KwokWing Shing Ho
May 28, 2017·Journal of Ethnopharmacology·Alan Santos OliveiraEnilton Aparecido Camargo
Jan 1, 2017·Critical Reviews in Immunology·George B StefanoMaynard H Makman

❮ Previous
Next ❯

Citations

Feb 6, 2021·BMC Pharmacology & Toxicology·Ioana-Mirela VasincuLenuța Profire

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.