Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents

Journal of Ethnopharmacology
Daniella K S LimaAdair Roberto Soares Santos

Abstract

Piper aleyreanum is a small tree that is widely distributed in tropical and subtropical regions, mostly in North and South America, and is used as an immunomodulator, analgesic and antidepressant in folk medicine. This study was designed to investigate the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oils from the aerial parts of Piper aleyreanum (EOPa) in rodents. The antinociceptive and anti-inflammatory effects of orally administered EOPa were evaluated in mice subjected to the formalin and pleurisy models, respectively. We also pretreated the rats with EOPa before acute ethanol-induced gastric lesions and measured gastric lesion extension and mucus and glutathione (GSH) levels in the gastric mucosa. Finally, we performed a phytochemical analysis of EOPa. The chemical composition of EOPa was analyzed by gas chromatography and mass spectrometry (GC/MS), which identified 35 compounds, representing 81.7% of total oil compounds. Caryophyllene oxide (11.5%), β-pinene (9%), spathulenol (6.7%), camphene (5.2%), β-elemene (4.7%), myrtenal (4.2%), verbenone (3.3%) and pinocarvone (3.1%) were the major oil constituents. The oral administration of EOPa (10-1000 mg/kg) significantly inhibited the ...Continue Reading

References

Oct 1, 1992·Pain·A TjølsenK Hole
Jul 1, 1992·British Journal of Pharmacology·M G HenriquesT J Williams
Nov 1, 1994·British Journal of Pharmacology·A TomlinsonD A Willoughby
Jun 1, 1996·British Journal of Pharmacology·T S SalehY S Medeiros
Dec 5, 1996·European Journal of Pharmacology·R O De CamposJ B Calixto
Jul 16, 1997·European Journal of Pharmacology·T S SalehY S Medeiros
Aug 27, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·A R SantosG A De Freitas
Nov 11, 1999·British Journal of Pharmacology·F NantelC C Chan
Dec 29, 2000·Phytochemistry·H M NavickieneM Furlan
May 16, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M G Repetto, S F Llesuy
Oct 3, 2002·Nature Reviews. Immunology·Toby LawrenceDerek W Gilroy
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·Sören SiegmundManfred V Singer
Mar 3, 2004·Planta medica·Toshio MorikawaMasayuki Yoshikawa
Mar 12, 2004·Journal of Ethnopharmacology·E S Sunila, G Kuttan
Feb 11, 2005·Current Opinion in Gastroenterology·Luke C Bi, Jonathan D Kaunitz
Jul 2, 2005·Expert Opinion on Emerging Drugs·J B CalixtoA R Santos
Jul 12, 2005·Journal of Ethnopharmacology·João B Calixto
Jun 6, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D P BezerraL V Costa-Lotufo
Apr 3, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·F Cícero Bezerra FelipeGlauce S de Barros Viana
May 26, 2007·The Journal of Pharmacy and Pharmacology·Sudipto GangulyMitali Chatterjee
Aug 11, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Naresh SinghBalaram Ghosh
Nov 3, 2007·Journal of Applied Toxicology : JAT·Daniel P BezerraLetícia V Costa-Lotufo
Nov 23, 2007·Journal of Natural Products·Joaquim V MarquesMassuo J Kato
Apr 9, 2008·Journal of Ethnopharmacology·Andrea M KoroishiBenedito P Dias Filho
Jul 2, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marta MenegazziSalvatore Cuzzocrea
May 19, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C Y YaoS L Pan
Oct 6, 2009·Biological & Pharmaceutical Bulletin·Rosely Valéria RodriguesAdair Roberto Soares Santos
Apr 28, 2010·Journal of Ethnopharmacology·Francine Bittencourt PotrichMaria Consuelo Andrade Marques
Apr 30, 2010·Memórias do Instituto Oswaldo Cruz·Lianet MonzoteMigdalia Miranda
May 24, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jerome SarrisAndrew Scholey
Sep 2, 2011·Chemical & Pharmaceutical Bulletin·Heidi Rose BokeschTawnya Carlene McKee
Oct 19, 2011·Parasitology Research·Lizandra G MagalhãesMárcio L A e Silva
Dec 17, 2011·International Journal of Molecular Sciences·Wan Mohd Nuzul Hakimi Wan SallehHasnah Mohd Sirat

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Citations

Oct 16, 2013·Peptides·Richard J Bodnar
Mar 29, 2014·Journal of Pharmaceutical and Biomedical Analysis·Lucas Maciel Mauriz MarquesAnderson Rodrigo Moraes de Oliveira
Jan 31, 2014·Journal of Medicinal Food·Francilene V SilvaRita C M Oliveira
Dec 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José Ferreira Sarmento-NetoDamião Pergentino de Sousa
Nov 8, 2015·Regulatory Toxicology and Pharmacology : RTP·Débora Regina Hoff BraitArielle Cristina Arena
Jul 13, 2013·Molecular Nutrition & Food Research·Bharat B AggarwalSubash C Gupta
Jul 22, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Norlaily Mohd AliNoorjahan Banu Alitheen
May 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weng-Keong ChanBey-Hing Goh
Jan 23, 2017·Journal of Ethnopharmacology·Lidiane Schultz BranquinhoArielle Cristina Arena
Dec 15, 2017·International Journal of Molecular Sciences·Joyce Kelly da SilvaWilliam N Setzer
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bahare SalehiWilliam N Setzer
Dec 11, 2019·Biomolecules·Diogo Vilar da FonsêcaDamião Pergentino de Sousa
Apr 4, 2017·TheScientificWorldJournal·Maria Christina Dos Santos VerdamObdulio Gomes Miguel
Jun 4, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Cynthia Germoglio Farias de MeloReinaldo Nóbrega de Almeida
Apr 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuanyuan ZhouKiho Lee
Mar 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Fernanda PetryLiz G Müller
Nov 7, 2020·Inflammopharmacology·Aline Aparecida SaldanhaJoão Máximo de Siqueira

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