Evaluation of the antioxidant and gastroprotective activity and HPLC analysis of the hydroalcoholic extract of Tocoyena formosa leaves (Cham. & Schlecht) K. Schum

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Francisco Rafael Alves Santana CesárioIrwin Rose Alencar de Menezes

Abstract

The peptic ulcer is a gastric disorder that affects millions of people and yet they cause many side effects. In this sense, natural products represent an important alternative to the discovery of compounds with gastroprotective activity. The present work has as its objective to evaluate the antioxidant and gastroprotective activity of the Hydroalcoholic Extract of Leaves from Tocoyena formosa (Cham. & Schlecht.) K. Schum (HELTF), this being much emphasized in traditional medicine for inflammatory morbidities and gastric symptoms. For the evaluation of the antioxidant activity, FRAP and DPPH tests were carried out, and for the evaluation of the gastroprotective activity, gastric lesion induction by ethanol, acidified ethanol, indomethacin and physical barrier tests were used. Antioxidant assay of HELTF revealed an EC50 of 558.66 μM FeSO4/g and IC50 of 189.78 μg/ml for FRAP and DPPH respectively. In gastroprotective, in ethanol model, all the doses presented significant activity in comparison to controls, however, in the gastric lesion induction test by acidified ethanol and indomethacin, only the dose of 200 mg/kg presented with significance. In the physical barrier test presented evidence that protection by the formation of a p...Continue Reading

Citations

Jun 19, 2020·TheScientificWorldJournal·Abdalbasit Adam Mariod, Suzy Munir Salama
Sep 24, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hong DuanKe-Feng Zhai
Aug 10, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bruno Oliveira de VerasPenha Patricia Cabral Ribeiro
Sep 3, 2021·Planta medica·Thaise BoeingArquimedes Gasparotto Junior

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.