Evaluation of the antiviral activity against Junin virus of macrocyclic trichothecenes produced by the hypocrealean epibiont of Baccharis coridifolia

Planta medica
Cybele C GarcíaElsa B Damonte

Abstract

Four macrocyclic trichothecenes, roridin A, roridin E, verrucarin A and verrucarin J, produced by the hypocrealean epibiont of Baccharis coridifolia, were evaluated for their inhibitory activity against the arenavirus Junin (JUNV), the etiological agent of Argentine hemorrhagic fever. The trichothecenes achieved a dose-dependent inhibition of JUNV multiplication at concentrations not affecting cell viability. The 50 % inhibitory concentration (IC50) values determined by a virus yield inhibition assay were in the range 1.2 - 4.9 ng/ml. The most active compound was verrucarin J which reduced JUNV yield more than 2 log units and had a similar effect against the arenavirus Tacaribe. The trichothecenes lacked virucidal effects on JUNV virions. From time of addition and removal experiments, it can be concluded that verrucarin J inhibited a late stage in the replicative cycle of JUNV, after 5 h of adsorption.

Citations

Jul 22, 2010·The Journal of Antibiotics·Arlene A Sy-CorderoNicholas H Oberlies
Jul 31, 2013·Virology Journal·María F Visintini JaimeLucia V Cavallaro
May 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Antônio Sérgio Nascimento MoreiraIvo José Curcino Vieira
May 12, 2017·Journal of Agricultural and Food Chemistry·Seung Mok RyuDongho Lee
Feb 6, 2020·Planta medica·Ying GaoHanli Ruan
Jun 19, 2009·Chemical Reviews·Stefan BräseCarl F Nising
Nov 21, 2018·Journal of Natural Products·Seoung Rak LeeKi Hyun Kim

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