Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review

Environmental Health Perspectives
Kyla W TaylorLars Lind

Abstract

Diabetes is a major threat to public health in the United States and worldwide. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. We assessed the epidemiologic literature for evidence of associations between persistent organic pollutants (POPs) and type 2 diabetes. Using a PubMed search and reference lists from relevant studies or review articles, we identified 72 epidemiological studies that investigated associations of persistent organic pollutants (POPs) with diabetes. We evaluated these studies for consistency, strengths and weaknesses of study design (including power and statistical methods), clinical diagnosis, exposure assessment, study population characteristics, and identification of data gaps and areas for future research. Heterogeneity of the studies precluded conducting a meta-analysis, but the overall evidence is sufficient for a positive association of some organochlorine POPs with type 2 diabetes. Collectively, these data are not sufficient to establish causality. Initial data mining revealed that the strongest positive correlation of diabetes with POPs occurred with organochlorine compounds, such as trans-nonachlor, dichl...Continue Reading

References

Oct 1, 1992·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·E EnanF Matsumura
Jan 1, 1990·Archives of Toxicology·J R GorskiK Rozman
Jan 1, 1988·Journal of Toxicology and Environmental Health·M S RaoD G Scarpelli
Oct 1, 1988·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·K EbnerF Matsumura
Jun 15, 1983·Toxicology and Applied Pharmacology·C L PotterD H Russell
May 1, 1994·Environmental Health Perspectives·H OlsenF Matsumura
May 1, 1997·Epidemiology·G L HenriksenJ A Swaby
Aug 26, 1998·Toxicology·C T LutzC R Petzold
May 14, 1999·The Journal of Clinical Endocrinology and Metabolism·J E MichalekJ L Kiel
Jul 27, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·M CranmerV A Fonseca
Aug 8, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·F El-SabeawyB Lasley
Sep 14, 2001·Occupational and Environmental Medicine·K SteenlandJ Michalek
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Dec 1, 2005·Environmental Health : a Global Access Science Source·Lars RylanderLars Hagmar
Apr 25, 2006·Pediatric Diabetes·Eba H HathoutJohn W Mace
Sep 29, 2006·American Journal of Industrial Medicine·Han K KangGenevieve M Matanoski
Dec 22, 2006·Occupational and Environmental Medicine·M S O'NeillJ Schwartz
Jul 12, 2007·Human & Experimental Toxicology·Anna Rignell-HydbomLars Hagmar
Oct 17, 2007·Environmental Health Perspectives·Neculai CodruDavid O Carpenter
Oct 26, 2007·Diabetes Care·W Susan ChengElizabeth Barrett-Connor
May 31, 2008·New Solutions : a Journal of Environmental and Occupational Health Policy : NS·Pamela Anderson-MahoneyJames Dahlgren

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Citations

Nov 23, 2013·Diabetes & Metabolism·D J MaglianoJ E Shaw
Dec 5, 2013·Diabetes Research and Clinical Practice·T TamayoW Rathmann
Apr 24, 2014·Current Diabetes Reports·Andrew G Kirkley, Robert M Sargis
Sep 24, 2013·Environmental Health Perspectives·Tine L M HectorsRonny Blust
Oct 23, 2014·Journal of Exposure Science & Environmental Epidemiology·Paul R EdenJanice E Chambers
Feb 16, 2016·The Science of the Total Environment·Melissa M SmarrGermaine M Buck Louis
Feb 28, 2015·Journal of Immunotoxicology·Marina Cetkovic-CvrljeHwee Kiat Gong
Feb 18, 2016·Reviews in Endocrine & Metabolic Disorders·Duk-Hee Lee, David R Jacobs
Feb 16, 2016·The Science of the Total Environment·Junlang QiuGangfeng Ouyang
Jan 1, 2016·Environment International·Samira SalihovicLars Lind
Nov 20, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rance NaultTimothy R Zacharewski
Sep 18, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kelly A FaderTimothy R Zacharewski
Oct 1, 2015·Environmental Health : a Global Access Science Source·Panu RantakokkoJussi Pihlajamäki
Dec 5, 2013·Environmental Research·Conny KarnesKyle Steenland
Mar 1, 2015·Environmental Research·Juan P ArrebolaNicolás Olea
Jan 1, 2014·The Science of the Total Environment·M PavukUNKNOWN Anniston Environmental Health Research Consortium
Apr 25, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C-X XuS A Tischkau
Mar 19, 2014·Occupational and Environmental Medicine·Omayma AlshaarawyMichael E Andrew
Apr 12, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gemma PerellóJosé L Domingo
May 20, 2015·Diabetology & Metabolic Syndrome·Elvis Ndonwi NgwaEugene Sobngwi
Apr 18, 2015·BioMed Research International·Johanna BodinUnni Cecilie Nygaard
Jan 28, 2015·Endocrine-related Cancer·Denise K ReavesJodie M Fleming
Jan 17, 2015·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Syam S AndraKonstantinos C Makris
Oct 3, 2014·Journal of Agromedicine·Matthew C Keifer, David L McClure
May 25, 2016·International Journal of Hygiene and Environmental Health·Martine VrijheidMark Nieuwenhuijsen
Jul 20, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·Lindsay M JaacksK M Venkat Narayan
Jun 14, 2016·Journal of Developmental Origins of Health and Disease·S FirminL Abdennebi-Najar
Jun 21, 2016·Diabetes & Metabolism·M Cheikh RouhouL Lamontagne

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