Evaluation of the association of zoonotic Ljungan virus with perinatal deaths and fetal malformation

Birth Defects Research. Part C, Embryo Today : Reviews
Lili ZhengHong Xin

Abstract

More and more epidemiologic and experimental data support the notion that Ljungan virus (LV), originally isolated from some rodent populations in Sweden, Denmark, and the United States, plays an important role in stillbirth and fetal malformation. Mouse dams infected with LV may result in uterine resorption and perinatal deaths that may cross generations, and their offspring may suffer high rates of malformations including cranial, brain, and limb malformations. In humans, researches founded that LV infection is related to malformation, intrauterine fetal death, and even central nervous system malformation. Although molecularly characterized, little is known about the biophysical nature of LV. Consequently, the role of LV infections in sudden infant death syndrome is still confusing, and the mechanism of how LV infections cause diseases is not clear. More research is clearly necessary to explore the mechanisms of LV infection in human and animal diseases to bring improvement to the clinical outcomes.

References

Apr 1, 1976·Journal of Wildlife Diseases·A J MainR C Wallis
Apr 1, 1994·Paediatric and Perinatal Epidemiology·R GreenwoodD Ashley
Mar 8, 2003·Archives of Pediatrics & Adolescent Medicine·J Bruce Beckwith
Mar 26, 2003·The Journal of General Virology·E Susanne JohanssonA Michael Lindberg
Aug 9, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Annika SamsioeBo Niklasson
Mar 6, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
Jul 20, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Maren ChanSeymour Rosen
May 17, 2008·International Journal of STD & AIDS·James Davis, J J Rufus Fernando
Oct 14, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Annika SamsioeWilliam Klitz
Nov 11, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G BenoistY Ville
Nov 11, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anita RiipinenMaria Söderlund-Venermo
Dec 11, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sonja A RasmussenDanielle S Ross
Jan 13, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Annika SamsioeBo Niklasson
Jan 31, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
May 2, 2009·Forensic Science, Medicine, and Pathology·Bo NiklassonWilliam Klitz
Sep 17, 2009·Forensic Science, Medicine, and Pathology·Henry F Krous, Neil E Langlois
Nov 11, 2009·The American Journal of Forensic Medicine and Pathology·Enrico SilingardiLorella Garagnani
Jul 28, 2010·Clinical Obstetrics and Gynecology·Elizabeth M McClureRobert L Goldenberg
Oct 5, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Henry F Krous, Neil E Langlois
Jul 9, 2011·Journal of Medical Virology·Bo Niklasson
May 15, 2012·Journal of Virological Methods·René KalliesMatthias Niedrig
Jul 16, 2013·Journal of Medical Virology·Anne J JääskeläinenOlli Vapalahti
Feb 4, 2014·Journal of Wildlife Diseases·Claudia RomeoHeidi C Hauffe

Related Concepts

Brain
Fetal Death
Fetus
Laboratory mice
Research
Rodent
Sudden Infant Death Syndrome
Virus Diseases
Evaluation
Deformity of Limb

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