EVALUATION OF THE BEHAVIOR OF LEVELS OF HMGB1 AND IL6 AS PREDICTORS OF INFECTION, ACUTE KIDNEY INJURY AND MORTALITY IN CIRRHOTIC PATIENTS WITH VARICEAL BLEEDING

Arquivos De Gastroenterologia
Eduardo Garcia VilelaMarcos Vinicius Melo de Andrade

Abstract

Gastroesophageal varices and associated bleeding are a major cause of morbidity and mortality in cirrhotic patients. To evaluate the potential role of the biomarkers HMGB1 (High Mobility Group Box 1) and IL-6 (Interleukin-6) as predictors of infection, acute kidney injury and mortality in these patients. It is a prospective, observational study that included 32 cirrhotic patients with variceal bleeding. The subjects'mean age was 52±5 years and 20 (62.5%) were male. The average MELD was 17.53±5 and the average MELD-Na was 20.63±6.06. Thirty patients (93.3%) patients were Child-Pugh class B or C. Infection was present in 9 subjects (28.1%), acute kidney injury was present in 6 (18.1%) and 4 (12.5%) patients died. The median serum levels of HMGB1 were 1487 pg/mL (0.1 to 8593.1) and the median serum level of IL-6 was 62.1 pg/mL (0.1 to 1102.4). The serum levels of HMGB1 and IL-6 were significantly higher in patients who developed infection, acute kidney injury and death (P<0.05). The Spearman's correlations for HMGB1 and IL-6 were 0.794 and 0.374 for infection, 0.53 and 0.374 for acute kidney injury and 0.467 and 0.404 for death, respectively. Serum levels of HMGB1 and IL-6 were higher in patients with the three studied outcomes. H...Continue Reading

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Citations

Jul 15, 2021·BMC Gastroenterology·Jae Heon KimOk-Jae Lee
Oct 20, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pooja Basthi MohanShiran Shetty

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