Evaluation of the biocompatibility of calcium phosphate cement/PLGA microparticle composites

Journal of Biomedical Materials Research. Part a
Dennis LinkJohn A Jansen

Abstract

In this study, the biocompatibility of a calcium phosphate (CaP) cement incorporating poly (D,L-lactic-co-glycolic acid) (PLGA) microparticles was evaluated in a subcutaneous implantation model in rats. Short-term biocompatibility was assessed using pure CaP discs and CaP discs incorporating PLGA microparticles (20% w/w) with and without preincubation in water. Long-term biocompatibility was assessed using CaP discs incorporating varying amounts (5, 10, or 20% w/w) and diameter sizes (small, 0-50 mum; medium, 51-100 mum, or large, 101-200 mum) of PLGA microparticles. The short-term biocompatibility results showed a mild tissue response for all implant formulations, irrespective of disc preincubation, during the early implantation periods up to 12 days. Quantitative histological evaluation revealed that the different implant formulations induced the formation of similar fibrous tissue capsules and interfaces. The results concerning long-term biocompatibility showed that all implants were surrounded by a thin connective tissue capsule (<10 layers of fibroblasts). Additionally, no significant differences in capsule and interface scores were observed between the different implant formulations. The implants containing 20% PLGA with ...Continue Reading

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Citations

May 4, 2012·Clinical Oral Investigations·Daniël A W OortgiesenJohn A Jansen
Mar 18, 2009·Journal of Materials Science. Materials in Medicine·Dan KaiXingdong Zhang
Sep 17, 2009·Journal of Materials Science. Materials in Medicine·A Champa Jayasuriya, Shane Kibbe
Oct 14, 2009·Journal of Materials Science. Materials in Medicine·Gangfeng HuPeijian Tong
Apr 15, 2010·Tissue Engineering. Part a·Hockin H K XuLaurence C Chow
Aug 12, 2015·Journal of Functional Biomaterials·Sergey V Dorozhkin
Jan 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·F C J van de WateringJ A Jansen
Jun 4, 2008·Journal of Biomedical Materials Research. Part a·Dennis P LinkJohn A Jansen
Oct 14, 2009·Biotechnology Progress·Joshua R PorterKetul C Popat
Sep 4, 2012·Journal of Biomedical Materials Research. Part a·Hueliton W KidoAna Claudia M Renno
Oct 31, 2013·Journal of Tissue Engineering and Regenerative Medicine·Hongbing LiaoJohn A Jansen
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May 4, 2012·Journal of Tissue Engineering and Regenerative Medicine·Daniël A W OortgiesenJohn A Jansen
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Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Tao YuJiandong Ye
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Aug 5, 2014·Journal of Biomedical Materials Research. Part a·Jan L PattersonSarah E Bondos
Jan 1, 2013·Journal of Functional Biomaterials·Sergey V Dorozhkin
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Jan 30, 2015·Journal of Materials Science. Materials in Medicine·Hueliton Wilian KidoAna Claudia Muniz Rennó
Apr 19, 2012·Journal of Tissue Engineering·Roman A PerezMaria-Pau Ginebra

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