PMID: 6110383Sep 1, 1980Paper

Evaluation of the bronchodilating and antiallergic properties of a beta-adrenoceptor stimulant, KWD 2131, in asthmatic patients

Allergy
K O Pegelow, K Strandberg

Abstract

KWD 2131 (1-(3,5-dihydroxyphenyl)-(1,1dimethyl-2-hydroxyethyl-amino/ethanol sulphate) is a beta-adrenoceptor stimulating compound that has been shown to be equipotent to terbutaline with regard to inhibition of anaphylactic histamine release from guinea pig lung tissue but less potent than terbutaline as a cardioaccelerator in this species. In the present study KWD 2131 was found to be about 5-10 times less potent than terbutaline as a cardioaccelerator, tremorogenic and bronchodilator agent on subcutaneous (s.c.) injection in man. S.c. injection of KWD 2131 in a subthreshold dose for bronchodilation, i.e. 0.3 mg or 0.6 mg, given prior to a bronchial provocation test with specific allergen had no protective effect on the changes in specific airway conductance and peak expiratory flow in a double-blind cross-over study in 12 patients with allergic asthma. It is concluded that KWD 2131 probably has a less selective antiallergic activity in man as compared to guinea pig and that the methodology employed for the evaluation is useful for the characterization of antiallergic drugs with bronchodilator properties.

References

Aug 20, 1977·Lancet·S T HolgateA E Tattersfield
May 1, 1978·Clinical Allergy·R PauwelsM Van Der Straeten
Feb 1, 1977·The Journal of Allergy and Clinical Immunology·S LarssonG Thiringer
May 1, 1977·The Journal of Allergy and Clinical Immunology·J W JenneF J Wall
Dec 1, 1977·The Journal of Allergy and Clinical Immunology·J W JenneF J Wall
Feb 1, 1977·Acta Allergologica·J P Girard, M Cuevas
May 1, 1978·Clinical Allergy·A MuittariT Veneskoski
Dec 8, 1973·British Medical Journal·D H BryantL Lazarus
Aug 1, 1974·The American Journal of Medicine·S M AyresR G Evans
Feb 1, 1969·Pediatric Clinics of North America·E A Bronsky, E F Ellis
Jan 1, 1951·International Archives of Allergy and Applied Immunology·H HERXHEIMER

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