Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study

BMJ : British Medical Journal
Robyn E WoottonClaire M A Haworth


To investigate whether the association between subjective wellbeing (subjective happiness and life satisfaction) and cardiometabolic health is causal. Two sample, bidirectional mendelian randomisation study. Genetic data taken from various cohorts comprised of the general population (mostly individuals of European ancestry, plus a small proportion of other ancestries); follow-up analysis included individuals from the United Kingdom. Summary data were used from previous genome wide association studies (number of participants ranging from 83 198 to 339 224), which investigated traits related to cardiovascular or metabolic health, had the largest sample sizes, and consisted of the most similar populations while minimising sample overlap. A follow-up analysis included 337 112 individuals from the UK Biobank (54% female (n=181 363), mean age 56.87 years (standard deviation 8.00) at recruitment). Subjective wellbeing and 11 measures of cardiometabolic health (coronary artery disease; myocardial infarction; total, high density lipoprotein, and low density lipoprotein cholesterol; diastolic and systolic blood pressure; body fat; waist to hip ratio; waist circumference; and body mass index). Evidence of a causal effect of body mass inde...Continue Reading


Nov 27, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Derek K TracySukhwinder S Shergill
Apr 16, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Uku VainikRené Mõttus
May 21, 2020·Blood Advances·Molly WentRichard S Houlston
Sep 16, 2020·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Joseph FirthBrendon Stubbs
Jul 1, 2020·BMJ : British Medical Journal·Joseph FirthEmeran A Mayer
Aug 27, 2019·Wellcome Open Research·Venexia M WalkerRichard M Martin
May 13, 2020·Nature Human Behaviour·K Paige Harden, Philipp D Koellinger
Apr 1, 2021·Frontiers in Cell and Developmental Biology·Shizheng QiuYang Hu
Apr 13, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Natalia Soldevila-DomenechJordi Alonso

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

International Journal of Psychology : Journal International De Psychologie
Louis Tay, Lauren Kuykendall
Nature Human Behaviour
Ed DienerLouis Tay
© 2021 Meta ULC. All rights reserved