Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study

BMJ : British Medical Journal
Robyn E WoottonClaire M A Haworth

Abstract

To investigate whether the association between subjective wellbeing (subjective happiness and life satisfaction) and cardiometabolic health is causal. Two sample, bidirectional mendelian randomisation study. Genetic data taken from various cohorts comprised of the general population (mostly individuals of European ancestry, plus a small proportion of other ancestries); follow-up analysis included individuals from the United Kingdom. Summary data were used from previous genome wide association studies (number of participants ranging from 83 198 to 339 224), which investigated traits related to cardiovascular or metabolic health, had the largest sample sizes, and consisted of the most similar populations while minimising sample overlap. A follow-up analysis included 337 112 individuals from the UK Biobank (54% female (n=181 363), mean age 56.87 years (standard deviation 8.00) at recruitment). Subjective wellbeing and 11 measures of cardiometabolic health (coronary artery disease; myocardial infarction; total, high density lipoprotein, and low density lipoprotein cholesterol; diastolic and systolic blood pressure; body fat; waist to hip ratio; waist circumference; and body mass index). Evidence of a causal effect of body mass inde...Continue Reading

Citations

Nov 27, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Derek K TracySukhwinder S Shergill
Apr 16, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Uku VainikRené Mõttus
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