Evaluation of the Cepheid Xpert SA Nasal Complete for direct detection of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in nasal swabs from pediatric patients.

Diagnostic Microbiology and Infectious Disease
Huanyu WangAmy L Leber

Abstract

Nasal carriers of Staphylococcus aureus (SA) are at increased risk for health-care associated infections with this organism. Timely detection of SA and Methicillin-resistant SA (MRSA) and subsequent decolonization are important components of infection control. While performance of nucleic acid amplification-based tests for detection of SA/MRSA in adults has been well-described, limited data are available in children. Our objective was to evaluate the performance of the Xpert SA in pediatric patients. Overall, for detection of SA, Xpert SA demonstrated a sensitivity and specificity of 95.1% and 93.5%, respectively and 87.8% sensitive and 98.1% specific for detection of MRSA. Performance in different age groups was similar but neonates had the lowest sensitivity and highest invalid rates. The Xpert SA is a rapid, reliable test to detect MSSA and MRSA nasal colonization in pediatric patients. Depending on the potential clinical impact, culture may be considered as a companion test to improve sensitivity.

References

Dec 10, 2003·Journal of Clinical Microbiology·Sharon J PeacockNicholas P J Day
May 29, 2007·The Pediatric Infectious Disease Journal·Ulrich HeiningerUNKNOWN PIGS/MRSA Study Group
Aug 19, 2007·The Journal of Hospital Infection·Jan Kluytmans
Sep 18, 2009·Journal of Clinical Microbiology·Cathrin BaumBarbara C Kahl
Dec 17, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William R Jarvis
Mar 26, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Aaron M MilstoneTrish M Perl
Jun 1, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C LaurentY Glupczynski
Oct 15, 2010·Journal of Clinical Microbiology·Surbhi Malhotra-KumarUNKNOWN MOSAR WP2 Study Team
Apr 15, 2011·The New England Journal of Medicine·Rajiv JainGary A Roselle
Oct 15, 2011·Journal of Clinical Microbiology·Anne Dubouix-BourandyJean-Marc Gandois
Oct 9, 2012·Journal of Microbiological Methods·Cynthia E ZimmermanDarrell P Chandler
Oct 20, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A PetersenA R Larsen
May 31, 2013·The New England Journal of Medicine·Susan S HuangUNKNOWN AHRQ DECIDE Network and Healthcare-Associated Infections Program
Nov 29, 2013·The Journal of Antimicrobial Chemotherapy·G K PatersonM A Holmes
Jul 11, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·V O Popoola, A M Milstone
Apr 16, 2015·American Journal of Clinical Pathology·Parul A PatelLance R Peterson
Aug 11, 2015·Diagnostic Microbiology and Infectious Disease·Stijn JonckheereHans De Beenhouwer
Apr 29, 2016·Journal of Clinical Microbiology·Eric T BeckNathan A Ledeboer
May 11, 2018·Journal of Clinical Microbiology·Gar-Hing LeeGeoffrey W Coombs
Sep 14, 2018·Clinical Microbiology Reviews·Sahreena Lakhundi, Kunyan Zhang
Aug 1, 2020·Annals of Clinical Microbiology and Antimicrobials·Jia TangChen Mingquan
Aug 11, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Archana BalamohanLorry G Rubin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.