Evaluation of the cholinergic hypothesis in Alzheimer's disease with neuropsychological methods

Aging Clinical and Experimental Research
Dimitrios FotiouM Nakou

Abstract

This study aimed at evaluating the cholinergic hypothesis in Alzheimer's disease (AD) patients utilizing the pupillometry method, cognitive tests and Hamilton Depression Rating Scale (HAM-D), as well as to examine whether a correlation between cognitive tests and pupillometry exists. Forty-two patients with mean age 69.2 ± 7.0 years and documented AD volunteered to participate in this study, while 33 healthy matched subjects served as controls. All subjects underwent a pupillometric measurement and performed the Wechsler Memory Scale (WMS) and Mini Mental State Examination (MMSE). Also, HAM-D was used to assess the severity of depressive symptoms. The pupillometric parameters studied were (1) latency for the onset of constriction (T1), (2) maximum constriction velocity (VCmax), and (3) maximum constriction acceleration (ACmax). In AD patients MMSE and WMS score were correlated with ACmax (r = -0.409, p < 0.05 and r = -0.513, p < 0.05, respectively) and VCmax (r = -0.664, p < 0.05 and r = -0.771, p < 0.05), respectively. Moreover, T1 was found to be significantly increased by 23 % (p < 0.05) in AD patients compared to healthy subjects. Conversely, the mean scores of VCmax and ACmax were significantly decreased in AD patients by ...Continue Reading

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Citations

Apr 30, 2019·Frontiers in Neurology·Pratik S ChouguleDan Milea
Oct 23, 2019·Signal Transduction and Targeted Therapy·Pei-Pei LiuJian-Sheng Kang
Sep 5, 2019·Postgraduate Medicine·Antonia KaltsatouGiorgos K Sakkas
Sep 16, 2019·Neuropsychologia·A P A BuenoM Hornberger
Aug 23, 2020·Signal Transduction and Targeted Therapy·Pei-Pei LiuJian-Sheng Kang
Jul 27, 2021·Frontiers in Chemistry·Adriana Ferreira Lopes VilelaCarmen Lúcia Cardoso

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