PMID: 19145495Jan 16, 2009Paper

Evaluation of the clinical staging for esophageal carcinoma after preoperative chemoradiation therapy

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Jian-Hua FuJing Wen

Abstract

To evaluate the accuracy of radiographic examination, endoscopic examination and clinical response evaluation criteria in staging for esophageal carcinoma after preoperative chemoradiation therapy(pre-CRT). Twenty-seven patients of locally advanced esophageal squamous cell carcinoma were involved. CT scan for cervical part, chest and abdomen, and endoscopic ultrasound(EUS), electronic fibrobroncoscopic examination were used to assess the tumor for staging before pre-CRT. The tumors were re-assessed using the same methods after the completion of CRT. Response evaluation criteria in solid tumors(RECIST) was used to assess the tumor response. Surgery was carried out 3 to 6 weeks after CRT. The clinical tumor response before surgery was compared with pathological tumor response after surgery. Micrometastasis detection was carried out for paraffin embedded lymph nodes using anti-keratin monoclonal marker AE1 and AE3 by immunohistochemical(IHC) method. The accuracy of CT scan in staging after pre-CRT was 40.9%(9/22) for primary tumors and 68.2%(15/22)for lymph nodes, with overall accuracy of 40.9%(9/22) for TNM staging. The accuracy of EUS in staging was 38.5%(5/13) for primary tumors and 69.2%(9/13) for lymph nodes, with overall acc...Continue Reading

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