Evaluation of the Common Molecular Basis in Alzheimer's and Parkinson's Diseases

International Journal of Molecular Sciences
Pratip RanaPreetam Ghosh

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative disorders related to aging. Though several risk factors are shared between these two diseases, the exact relationship between them is still unknown. In this paper, we analyzed how these two diseases relate to each other from the genomic, epigenomic, and transcriptomic viewpoints. Using an extensive literature mining, we first accumulated the list of genes from major genome-wide association (GWAS) studies. Based on these GWAS studies, we observed that only one gene (HLA-DRB5) was shared between AD and PD. A subsequent literature search identified a few other genes involved in these two diseases, among which SIRT1 seemed to be the most prominent one. While we listed all the miRNAs that have been previously reported for AD and PD separately, we found only 15 different miRNAs that were reported in both diseases. In order to get better insights, we predicted the gene co-expression network for both AD and PD using network analysis algorithms applied to two GEO datasets. The network analysis revealed six clusters of genes related to AD and four clusters of genes related to PD; however, there was very low functional similarity between these clus...Continue Reading

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Citations

Sep 8, 2020·Neuromolecular Medicine·Zi-Xuan WangAng Xing
Sep 29, 2020·Frontiers in Neuroscience·María Teresa Flores-DorantesRuth Gutiérrez-Aguilar
Feb 3, 2021·International Journal of Molecular Sciences·Cosima Damiana CalvanoTommaso Cataldi
Feb 15, 2021·Neuroscience Letters·Vasileios SiokasEfthimios Dardiotis

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Methods Mentioned

BETA
RNA-seq

Software Mentioned

DAVID
phenomiR
R
Scopus
CUDA
GENIE3
LIMMAto
Gephi
ToppGene
networkX

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