Evaluation of the constitutive properties of native, tissue engineered, and degenerated articular cartilage

Clinical Biomechanics
A SeifzadehM Papini

Abstract

Conventional models to evaluate degenerated cartilage do not consider nonlinear permeability and proteoglycan viscous effects. Some models also utilize spring elements to represent the viscous effects of the fibers, thus application tothe modeling of nonuniform deformations such as those that occur in indentation tests. The purpose of this study was to assess the changes in the mechanical behavior of tissue engineered and degraded cartilage while addressing these shortcomings and limitations. An inverse finite element method was used to determine the material properties of native and tissue engineered cartilage from indentation test data. The engineered cartilage was evaluated 3 and 9 months after implantation into osteochondral defects in the trochlear groove of sheep stifles. The strain rate dependent responses of the engineered and native cartilage in unconfined compression were also determined for strain rates ranging from 0 to 20% s(-1). The material properties of bovine cartilage before and after proteoglycan depletion and collagen degradation were also compared using unconfined compression test data from the literature. For a given strain, the stiffness of the engineered cartilage was approximately one tenth of that of t...Continue Reading

References

Feb 1, 1984·Annals of the Rheumatic Diseases·R D AltmanD S Howell
Nov 1, 1993·Journal of Biomechanical Engineering·V C MowR L Spilker
Oct 1, 1996·Journal of Biomechanics·M Argoubi, A Shirazi-Adl
Mar 28, 2006·Biomaterials·R A KandelUNKNOWN CIHR-Bioengineering of Skeletal Tissues Team

❮ Previous
Next ❯

Citations

Feb 16, 2013·Tissue Engineering. Part C, Methods·Tim W G M SpittersMarcel Karperien
Mar 18, 2015·Biomechanics and Modeling in Mechanobiology·J MabumaW Ehlers
Aug 15, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Yasaman Niki, Alireza Seifzadeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.