PMID: 9535542Apr 16, 1998Paper

Evaluation of the cutaneous anti-inflammatory activity of azaspiranes

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
D E GriswoldM Chabot-Fletcher

Abstract

The ability of azaspiranes to modulate the acute inflammatory response in models of skin inflammation was examined. The in vivo experiments involved the use of 5-6 age-matched male Balb/c inbred mice (22-25 g) per treatment group and a control group of 8-10 animals. In vitro mechanistic studies used RBL-1 and U937 cells lines and freshly isolated human monocytes. Arachidonic acid (AA) (2 mg/20 microl in acetone) or PMA (phorbol myristate acetate) (4 microg/20 microl) were applied topically. SK&F 106615 and SK&F 106610 were administered topically either dissolved in acetone or dimethylacetamide just after the application of the irritant. Isolated cells were treated with the compounds dissolved in DMSO. The thickness and influx of neutrophils into the treated ears was measured as was the effects of the azaspiranes on 5-lipoxygenase activity, cyclooxygenase activity, prostaglandin and leukotriene synthesis, and the activation of the transcription factor NF-kappaB. SK&F 106615 and SK&F 106610 significantly reduced inflammation in the AA- and PMA-induced inflammation models (p < 0.05) with ED50's of 179 and 120 mg/ear for edema and myeloperoxidase, respectively. The compounds did not inhibit eicosanoid biosynthesis, have a direct ef...Continue Reading

Citations

Aug 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Mohamed EddouksNaoufel Ali Zeggwagh
May 15, 2009·Journal of Ethnopharmacology·Ivones HernándezGabino Garrido
Jun 27, 2009·Experimental Dermatology·Anthony DellingerChristopher L Kepley
Jun 10, 2009·The American Journal of Chinese Medicine·Mohammed Nurul Absar KhanYong-Ki Hong
Aug 28, 2021·International Journal of Molecular Sciences·Paola Bustos-SalgadoMaría Luisa Garduño-Ramírez

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