Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides.

Anais Brasileiros De Dermatologia
Gustavo Moreira AmorimMárcia Ramos-E-Silva

Abstract

Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. Small sample and its retrospective analysis. Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.

References

Apr 18, 2000·Archives of Dermatology·R van DoornR Willemze
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Aug 2, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rakhshandra TalpurMadeleine Duvic
Dec 1, 2012·Anais Brasileiros De Dermatologia·Thamy YamashitaSilvio Alencar Marques
Jun 6, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E C BentonS J Whittaker
Jan 21, 2014·Journal of the American Academy of Dermatology·Sarah I JawedChristiane Querfeld
Mar 20, 2014·The British Journal of Dermatology·J J ScarisbrickP Quaglino
Jul 22, 2014·American Journal of Hematology·Ryan A Wilcox
Aug 25, 2016·The British Journal of Dermatology·V NikolaouC Antoniou
Nov 10, 2016·Anais Brasileiros De Dermatologia·Renata Nahas Cardili, Ana Maria Roselino

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Citations

Oct 24, 2020·British Journal of Haematology·Julia J ScarisbrickPablo L Ortiz-Romero
Aug 5, 2021·The Journal of Dermatology·Tomomitsu Miyagaki

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