Evaluation of the cytogenetic effects of (131)I preceded by recombinant human thyrotropin (rhTSH) in peripheral lymphocytes of Wistar rats.

Radiation and Environmental Biophysics
Márcia Augusta da SilvaKayo Okazaki

Abstract

The present study was carried out to investigate the cytogenetic effects of therapeutic exposure to radioiodine preceded by rhTSH in an animal model. Three groups of Wistar rats (n = 6) were used: one group was treated only with (131)I (11.1 MBq/animal); the other two groups received rhTSH (1.2 mug/rat of either Thyrogen or rhTSH-IPEN, respectively) 24 h before administration of radioiodine. The percentage of lymphocytes with chromosome aberrations and the average number of aberrations and of dicentrics per cell were determined on blood samples collected 24 h, 7 and 30 days after administration of (131)I. The data show that the treatment with radioiodine alone or associated with rhTSH resulted in a greater quantity of chromosome alterations in relation to basal values after 24 h, with a gradual decline after 7 and 30 days of treatment. An increase in chromosome alterations was also seen after rhTSH treatment alone. Neither of the treatments, i.e., with (131)I alone or associated with hormone, resulted in an aneugenic effect or influenced the kinetics of cellular proliferation in rat blood lymphocytes. There was no significant difference between the cytogenetic effects of Thyrogen and rhTSH-IPEN treatment. These data suggest tha...Continue Reading

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Citations

Feb 1, 2014·BMC Complementary and Alternative Medicine·Elisângela DüsmanVeronica Elisa Pimenta Vicentini
Aug 26, 2011·Radiation and Environmental Biophysics·Elisângela DüsmanVeronica Elisa Pimenta Vicentini
Jul 8, 2016·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Ayşegül ÖzdalÖzgül Turhal

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