Evaluation of the development of lung hypoplasia in the premature lamb

Archives of Gynecology and Obstetrics
L HellmeyerS Schmidt

Abstract

The death rate from human diaphragmatic hernia (CDH) ranges from 50 to 80%, mainly due to the associated lung hypoplasia. To prevent these irreversible pathological and physical defects, the question of intrauterine surgical intervention arises. The histological changes of the lung tissue after inducement of a diaphragmatic hernia were examined. Of special interest was the time elapsing until the development of lung hypoplasia. A model of intrauterine inducement of diaphragmatic hernia was established using five fetal lambs to study consecutive pulmonary hypoplasia. Inducement of a diaphragmatic hernia was undertaken between 105 and 108 days' gestation. Lung tissue was examined histologically on postoperative days 8, 17, 21, 22, and 25 after inducement of the defect. On postoperative days 8, 17, and 21, no signs of pulmonary hypoplasia were found on histological examination. A pulmonary hypoplasia was found in two fetuses (on the 22nd and 25th postoperative day). The pathological and anatomical examination of a unilateral pulmonary hypoplasia after a short period of time shows that the artificially created diaphragmatic defect is a good model for producing a congenital diaphragmatic hernia. The severity of the pulmonary hypopla...Continue Reading

References

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Citations

May 10, 2011·Revue des maladies respiratoires·A LabbéP-J Déchelotte
Jan 13, 2009·Pediatric Pulmonology·Jacques C JaniJan A Deprest
May 29, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Christian Sosa-SosaRubén A Quintero
May 1, 2007·Pediatric Pulmonology·Andreas W FlemmerJan A Deprest
Oct 15, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shannon N AckerJason Gien

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