PMID: 8603797Jan 1, 1996Paper

Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
S K AgarwalC L Hughes

Abstract

Two experiments evaluating functional endpoints pertaining to the developmental neuroendocrine effects of aluminum in the rat are reported. A total of 31 timed mated dams were fed by daily gastric gavage 0, 5, 25, 50, 250, 500 or 1000 mg/kg body weight/day aluminum as a solution of aluminum lactate in distilled water from days 5 to 15 of gestation. The 390 offspring were evaluated for morphological and physiological parameters of reproductive functioning, including birth weight, anogenital distance (AGD), timing of vaginal opening, regularly of oestrous cycles, duration of pseudopregnancy (PSP), number of superovulated oocytes, and gonadal weight. No consistent or reproducible findings suggestive of toxic effect were found in the parameters of birth weight, AGD, timing of vaginal opening, duration of PSP, number of superovulated oocytes, and adult gonadal weight. A temporary increase in the proportion of aberrant oestrous cycles was detected during the first four cycles after vaginal opening, in the 250 mg/body weight/day group, with none by the fifth consecutive oestrous cycle. These results suggest that, apart from a transient disturbance of oestrous cycle regularity, aluminum does not have a developmental reproductive toxic ...Continue Reading

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Citations

Jun 8, 2011·Biological Trace Element Research·Hao SunYanfei Li
Sep 30, 2000·Journal of Neurosurgery·K Al MoutaeryM Tariq
Dec 29, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Zhen LiuJun Zhu
Jul 29, 2016·Immunologic Research·Shaye KivityYehuda Shoenfeld
Sep 2, 2020·Critical Reviews in Toxicology·Robert A Yokel
Oct 4, 2020·Environmental Toxicology and Pharmacology·Fatma M El-DemerdashAnsam B Al Mhanna

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