Evaluation of the "Dip Effect" Phenomenon in Antifungal Susceptibility Testing of Candida spp. against Echinocandins by Use of Gradient Concentration Strips

Journal of Clinical Microbiology
Maria SiopiJoseph Meletiadis

Abstract

The "dip effect" phenomenon complicates antifungal susceptibility testing with gradient concentration strips. Of 60 Candida isolates tested with the three echinocandins, this phenomenon was observed only for caspofungin with most (>90%) Candida albicans, Candida glabrata, and Candida tropicalis isolates and for isolates with CLSI MICs of ≤0.25 mg/liter. In order to facilitate MIC determination, a practical approach was developed using the inhibition zones at 32, 8, 2, and 1 mg/liter, increasing the agreement with the CLSI method >86%.

References

Aug 19, 2007·Annals of Clinical Microbiology and Antimicrobials·Inneke M van der HeijdenSilvia F Costa
Sep 26, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E DannaouiS Bretagne
May 9, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Maiken C ArendrupUNKNOWN EUCAST-AFST
Aug 21, 2012·Bioorganic & Medicinal Chemistry·Muthu K KathiravanSandeep Gadhwe

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