Jul 1, 1976

Evaluation of the discriminative effects of morphine in the rat

The Journal of Pharmacology and Experimental Therapeutics
H E Shannon, S G Holtzman

Abstract

The discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete trial avoidance task. Stimulus control of behavior was attained with a dose of morphine one-third to one-tenth of that used in previous studies. Morphine produced dose-related discriminative effects over a 100-fold dose range. The stimulus control produced by the discriminative effects of morphine met the following criteria for classification as a specific narcotic effect: 1) oxymorphone, levorphanol, methadone and meperidine, narcotic analgesics from diverse chemical families, also produced dose-related morphine-like discriminative effects; 2) dextrorphan and thebaine, compounds structurally related to the narcotics but lacking narcotic activity, failed to produce morphine-like discriminative effects; 3) effects were blocked by the narcotic antagonist naloxone; and 4) tolerance to the discriminative effects developed upon the repeated administration of morphine and cross-tolerance extended to methadone. The discriminative effects produced by morphine were further characterized by evaluating the capacity of prototypes of other classes of psychoactive drugs to produce morphine-like discriminative effects. Profadol and pentazoci...Continue Reading

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Mentioned in this Paper

Pentazocine
Analgesics, Non-Narcotic
Discrimination Learning
Reaction Time
Naloxone
Discrimination (Process of Differentiation)
Structure-Activity Relationship
Morphine Measurement
Meperidine
Narcotics

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