Evaluation of the duration of the antibiotic prophylaxis in paediatric postoperative heart surgery patients.

Pediatric Cardiology
Pablo ÁlvarezVincent Modesto

Abstract

The ideal duration of postoperative antibiotic prophylaxis in heart surgery is unknown. The most recent guidelines recommend a decrease in prophylaxis time to decrease the emergence of multiresistant germs. However, compliance with these recommendations is scant. Our aim was to determine whether a decrease in prophylaxis time entails an increase in the infection rate. A retrospective study was performed between September 2003 and March 2006, including all patients of ages between 1 day and 14 years who were admitted to the intensive care unit after heart surgery. Patients being treated for an infection at the time of surgery were excluded. The appearance of nosocomial infection, localisation, and the causative agent, if isolated, were included; demographic and clinical analytical variables, duration and type of antibiotic prophylaxis, and duration of other invasive devices were also included. Standard analysis and multivariable logistical regression were performed. 194 patients were included in the study. The median duration of antibiotic prophylaxis was 72 h (range 24 to 176), with the most-used prophylaxis regimen being second-generation cephalosporins plus aminoglycosides. The incidence of nosocomial infection, mainly bacter...Continue Reading

References

Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Apr 12, 2005·American Journal of Surgery·Dale W BratzlerUNKNOWN Surgical Infection Prevention Guideline Writers Workgroup
Dec 22, 2005·The Annals of Thoracic Surgery·Fred H EdwardsUNKNOWN Society of Thoracic Surgeons
Mar 27, 2007·The Annals of Thoracic Surgery·Richard EngelmanUNKNOWN Workforce on Evidence-Based Medicine, Society of Thoracic Surgeons
Jul 16, 2008·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M T Guardia CamíM Urrea Ayala

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Citations

Jul 20, 2014·The Annals of Thoracic Surgery·Meghan T MurrayGanga Krishnamurthy
May 27, 2014·Infectious Disease Clinics of North America·Joseph B Cantey, Sameer J Patel
Jun 2, 2016·The Journal of Thoracic and Cardiovascular Surgery·Sundeep BathR Brigg Turner
Feb 15, 2019·Surgical Infections·Radoslaw JaworskiBohdan Maruszewski
Jan 19, 2019·Current Pediatric Reviews·Despoina Gkentzi, Gabriel Dimitriou
Nov 26, 2014·Annals of Surgery·Jeannette P SoUNKNOWN SickKids Surgical Site Infection Task Force
Aug 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ruston S Taylor, Lara S Shekerdemian
Aug 10, 2018·Journal of Intensive Care Medicine·Joseph PhilipMark S Bleiweis
Nov 25, 2020·The Pediatric Infectious Disease Journal·Gian Maria TönzPhilipp Kwame Abayie Agyeman

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