Evaluation of the early response and mechanism of treatment of Parkinson's disease with L-dopa using (18)F-fallypride micro-positron emission tomography scanning

Experimental and Therapeutic Medicine
Yi-Hua FaYi-Wei Wu

Abstract

The aim of the present study was to investigate the use of (18)F-fallypride micro-positron emission tomography (micro-PET) imaging in the evaluation of the early therapeutic efficacy of L-dopa in the treatment of Parkinson's disease (PD) and the underlying mechanism. (18)F-fallypride was synthesized and its specific binding with dopamine (DA) receptors in normal mouse brain was studied. Following the establishment of a mouse model of PD, the animals were divided into normal control, PD model and L-dopa treatment groups. General behavior, swimming test, locomotor activity counts, transmission electron microscopy, immunohistochemical analysis, high performance liquid chromatography-electrochemical detection and (18)F-fallypride micro-PET imaging were used to study intergroup differences and the correlation between the changes of striatal uptake of (18)F-fallypride and the therapeutic efficacy. The general behavioral features of PD model mice were similar to the clinical symptoms of PD patients and were alleviated after treatment. The swimming time, locomotor activity and frequency of standing posture of PD model mice were lower than those of the control mice, but had no difference from those of the control mice after L-dopa treat...Continue Reading

References

Feb 1, 1987·Journal of the Neurological Sciences·G A DonnanP Rowe
Jan 5, 2002·Journal of Neural Transmission·N Schmidt, B Ferger
Jan 16, 2007·Toxicology·Nikolay M FilipovShannon C Sistrunk
Oct 31, 2009·Nuclear Medicine and Biology·Mohammed N TantawyTodd E Peterson
Sep 18, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Axel RomingerPaul Cumming
Oct 21, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Marta G VučkovićGiselle M Petzinger
Aug 31, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jenny CeccariniKoen Van Laere
Apr 12, 2014·International Journal of Molecular Sciences·Aminu Umar KuraSamer Hasan Hussein-Al-Ali
Sep 11, 2014·Frontiers in Neuroanatomy·Domingo Afonso-OramasTomás González-Hernández

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BETA
imaging technique
MDA

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SPSS

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