PMID: 9178239Jun 1, 1997Paper

Evaluation of the early response in fMRI in individual subjects using short stimulus duration

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
X HuK Ugurbil

Abstract

Optical imaging studies have provided evidence of an initial increase in deoxyhemoglobin following the onset of neuronal stimulation/activation and demonstrated that this initial increase could be spatially more specific to the site of neuronal activity. These studies also raised the possibility of improving the specificity of fMRI by selective mapping of this early response. Previous MR studies reported the observation of this early response but were limited in scope and not in full agreement. This paper presents a more extensive study that (a) demonstrates the initial signal decrease in individual subjects and (b) examines its dependence on stimulus duration and subject. Binocular visual stimulation experiments were performed on 14 subjects using echo-planar imaging (EPI) with high temporal resolution. An initial signal decrease was consistently observed in regions that were more localized than those displaying the delayed positive response. In agreement with previous fMRI and optical imaging findings, the maximum signal decrease was 1-2% and occurred at approximately 2 s after the onset of the stimulus, depending on the subject. For stimulus longer then 3.0 s, the temporal dynamics and the amount of signal change of the earl...Continue Reading

References

Sep 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·J FrahmW Hänicke
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A GrinvaldE Bartfeld
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Apr 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S OgawaP Glynn
Oct 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S Ogawa, T M Lee
Jul 1, 1984·Stroke; a Journal of Cerebral Circulation·P PantanoD Comar
Aug 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X HuP Erhard
Jul 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J L BoxermanR M Weisskoff
Mar 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R S MenonK Uğurbil
Jul 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T Ernst, J Hennig
Jan 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K ButtsC R Jack
Nov 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G C McKinnon
Aug 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R S MenonK Uğurbil
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S LaiR Friedland
Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A W SongJ S Hyde
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T H Le, X Hu
Jun 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S G KimK Uğurbil
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X Hu, T H Le

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Citations

Mar 18, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R S Menon, B G Goodyear
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S C Ngan, X Hu
Jun 17, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E Yacoub, X Hu
Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X GolayP Boesiger
Jul 14, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G H GloverD Ress
Feb 17, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E Yacoub, X Hu
Feb 17, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T H LeT P Roberts
Oct 25, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T MildnerC J Wiggins
Apr 16, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W ChenK Ugurbil
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R B BuxtonL R Frank
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P FranssonJ Frahm
Dec 5, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R P KennanJ C Gore
Dec 18, 2001·NMR in Biomedicine·E YacoubX Hu
Dec 1, 2006·Brain Topography·Takenori AkiyamaToshinori Kato
Nov 25, 2003·Current Opinion in Neurobiology·Dae-Shik Kim, Michael Garwood
Jan 17, 2004·Magnetic Resonance Imaging·G GarreffaB Maraviglia
Jan 17, 2004·Magnetic Resonance Imaging·Kâmil UğurbilXiao-Hong Zhu
Mar 10, 2004·NeuroImage·Dae-Shik KimLouis J Toth
Jan 22, 2003·Trends in Neurosciences·Kâmil UğurbilDae Shik Kim
May 15, 2003·Trends in Neurosciences·Nader PouratianArthur W Toga
Nov 6, 2003·Magnetic Resonance Imaging·Tianlu Li, Allen W Song
Jan 15, 1999·Magnetic Resonance Imaging·P FranssonJ Frahm
Feb 10, 2000·Brain Research. Cognitive Brain Research·A DoveD Y von Cramon
May 16, 2002·Artificial Intelligence in Medicine·Shing Chung NganXiaoping Hu
Apr 13, 2001·Current Opinion in Neurobiology·E Zarahn
Nov 7, 2002·Journal of Magnetic Resonance·Qing X YangMichael B Smith
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·T Q DuongS G Kim
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·D MalonekA Grinvald
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·M E Raichle
May 8, 2013·Cerebral Cortex·Amir OmidvarniaSampsa Vanhatalo
Oct 4, 2006·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Suzanne BakerThom Carney
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A M Howseman, R W Bowtell
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K UğurbilA Georgopoulos
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K M PeterssonA P Holmes
Sep 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nikos K Logothetis

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