PMID: 19920707Dec 1, 1995Paper

Evaluation of the effect of aging on the retinal nerve fiber layer thickness using scanning laser polarimetry

Journal of Glaucoma
Q M ChiY Kitazawa

Abstract

The scanning laser polarimeter is a new diagnostic scanning laser instrument that uses the polarizing properties of the retinal nerve fiber layer to measure its thickness in vivo. We first ascertained the measurement reproducibility of this instrument and then evaluated the effects of aging on the retinal nerve fiber layer. We performed three consecutive measurements in six glaucomatous and six age-matched normal healthy eyes to evaluate the instrumentation. The mean thickness of the peripapillary retinal nerve fiber layer within the rings 1. 0, 1. 5, and 2. 0 disk diameters from the center of the optic nerve head was calculated. We then evaluated aging effects on the retinal nerve fiber layer thickness in 75 eyes of 75 normal volunteers 20-66 years of age. The mean coefficients of variation of the measurements of the 1. 0, 1. 5, and 2. 0 disk diameters were 3. 64, 3. 59, and 4. 10, respectively, for the normal subjects, and 10. 20, 5. 65, 6. 08, respectively, for the patients with glaucoma. We found a significant, inverse linear correlation between age and the retinal nerve fiber layer thickness when measured along the 1. 5 disk diameter ring (R = 0. 16, p = 0. 0004). Significant decreases with aging also were observed in the ...Continue Reading

Citations

Jun 1, 2001·American Journal of Ophthalmology·Y KurimotoN Yoshimura
Jul 4, 2002·American Journal of Ophthalmology·David S GreenfieldRobert N Weinreb
Jun 18, 1999·American Journal of Ophthalmology·A BhandariR P Mills
Apr 15, 2000·American Journal of Ophthalmology·R Gürses-OzdenR Ritch
Apr 17, 2002·Journal of Cataract and Refractive Surgery·Michael S KookKyung- rhee Kim
May 31, 2001·Ophthalmology·D S Greenfield, R W Knighton
Dec 1, 1996·Ophthalmology·R VarmaE Barron
May 1, 2007·Ophthalmology·Rajul S ParikhRavi Thomas
Jan 11, 2007·Ophthalmology·Donald L BudenzJames Tielsch
Oct 9, 2001·American Journal of Ophthalmology·R Gürses-OzdenR Ritch
Dec 15, 2016·Ophthalmic Epidemiology·Tarannum Mansoori, Nagalla Balakrishna
Aug 10, 2002·Journal of Glaucoma·Takenori Takamoto, Bernard Schwartz
Jan 6, 2004·Journal of Glaucoma·Thomas P ColenHans G Lemij
Apr 17, 2004·International Ophthalmology Clinics·Harmohina Bagga, David S Greenfield
Feb 27, 2001·Current Opinion in Ophthalmology·H G Lemij
Jun 7, 2012·Korean Journal of Ophthalmology : KJO·Jong Yeon LeeYong Yeon Kim
Apr 18, 2007·Journal of Glaucoma·Felipe A MedeirosRobert N Weinreb
Mar 7, 2002·Current Opinion in Ophthalmology·David S Greenfield

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