Evaluation of the Effect of Enteral Lipid Sensing on Endogenous Glucose Production in Humans

Diabetes
Changting XiaoGary F Lewis

Abstract

Administration of lipids into the upper intestine of rats has been shown to acutely decrease endogenous glucose production (EGP) in the preabsorptive state, postulated to act through a gut-brain-liver axis involving accumulation of long-chain fatty acyl-CoA, release of cholecystokinin, and subsequent neuronal signaling. It remains unknown, however, whether a similar gut-brain-liver axis is operative in humans. Here, we infused 20% Intralipid (a synthetic lipid emulsion) or saline intraduodenally for 90 min at 30 mL/h, 4 to 6 weeks apart, in random order, in nine healthy men. EGP was assessed under pancreatic clamp conditions with stable isotope enrichment techniques. Under these experimental conditions, intraduodenal infusion of Intralipid, compared with saline, did not affect plasma glucose concentration or EGP throughout the study period. We conclude that Intralipid infusion into the duodenum at this rate does not elicit detectable effects on glucose homeostasis or EGP in healthy men, which may reflect important interspecies differences between rodents and humans with respect to the putative gut-brain-liver axis.

References

Mar 1, 2005·Nature Medicine·Tony K T LamLuciano Rossetti
Jun 11, 2009·Physiology·Carol K L LamTony K T Lam
Aug 7, 2009·Cell Metabolism·Grace W C CheungTony K T Lam
Aug 28, 2009·Cell Biochemistry and Function·Eduardo KokubunHorst Haebisch
Apr 12, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Changting XiaoGary F Lewis
Jun 28, 2013·The American Journal of Clinical Nutrition·Amy T RyanChristine Feinle-Bisset

❮ Previous
Next ❯

Citations

Dec 3, 2015·Current Opinion in Lipidology·Sarah FarrKhosrow Adeli
Aug 9, 2016·The Journal of Endocrinology·Paige V Bauer, Frank A Duca
May 17, 2018·Physiological Reviews·Sofiya GanchevaMichael Roden
Aug 2, 2018·Physiological Reviews·Max C Petersen, Gerald I Shulman
Feb 12, 2021·Nature Communications·Frank A DucaTony K T Lam

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.