Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats.

Indian Journal of Pharmacology
VijayalakshmiShobha Kamath

Abstract

Memory loss is universal and is the first symptom to manifest in majority of the patients suffering from Alzheimer's disease. This study is designed to investigate the effect of Ferula asafoetida linn. (F. foetida) extract on learning and memory in rats. Learning and memory were evaluated using elevated plus maze and passive avoidance paradigm after the oral administration of two doses (200 mg/kg and 400 mg/kg) of F. foetida aqueous extract with rivastigmine as positive control. Brain cholinesterase activity, serum thiols and cholesterol were also estimated. Extract produced significant improvement in memory score i.e. step through latency at 400 mg/kg dose in passive avoidance model (P< 0.05) and dose-dependent improvement of transfer latency in elevated plus maze model (P< 0.001). Dose-dependent inhibition of brain cholinesterase (P< 0.001) and significant improvement in antioxidant levels (P< 0.05) were also noted. Memory enhancing potential of F. foetida can be attributed to acetylcholinesterase inhibiting and antioxidant properties. Hence, dietary usage of F. foetida is beneficial and can also be employed as an adjuvant to existing anti-dementia therapies.

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Citations

Mar 20, 2015·American Journal of Alzheimer's Disease and Other Dementias·Seyyed Majid Bagheri, Mohammad Hossein Dashti-R
May 20, 2017·World Journal of Gastroenterology : WJG·Lin LiYang Xu
Feb 9, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Roja RahimiMaryam Noroozian
May 6, 2020·Mini Reviews in Medicinal Chemistry·Mohammad SabzehzariAmirhossein Sahebkar
Jan 24, 2021·Journal of Ethnopharmacology·Maciel da Costa AlvesJuliana Késsia Barbosa Soares
Apr 22, 2021·CNS & Neurological Disorders Drug Targets·Himanshi Varshney, Yasir Hasan Siddique

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