Evaluation of the effect of insulin sensitivity-enhancing lifestyle- and dietary-related adjuncts on antidepressant treatment response: protocol for a systematic review and meta-analysis

Systematic Reviews
Olaitan J JeremiahBenedict K Ryan

Abstract

Depression is the leading cause of disability worldwide and is known to be associated with insulin resistance (IR). Insulin resistance worsens the symptoms of depression and reduces the effectiveness of antidepressant medications in some depressed patients. Many studies have assessed the effect of adjunctive exercise, vitamin D supplementation, zinc supplementation, magnesium, probiotics, unsaturated fatty acids, and hygienic-dietary recommendations (sleep hygiene, healthy diet, physical activity, and sunlight exposure, combined or singly used), individually, on antidepressant treatment response. However, despite the reported insulin sensitivity-enhancing potential of these adjuncts, no systematic review has collectively analysed their antidepressant effect with regards to insulin sensitivity. In this systematic review, we will analyse the effect of the above-stated adjuncts on antidepressant treatment response (primary outcome) in comparison with treatment as usual with or without adjunctive placebo after identifying the relevant trials from a systematic literature search. Randomised controlled trials involving clinically depressed patients with diagnosis of major depressive, dysthymic or bipolar disorder will be considered. C...Continue Reading

References

Dec 20, 2005·Journal of Clinical Epidemiology·Toshi A FurukawaNorio Watanabe
Jun 26, 2007·Behavioural Brain Research·Moses A AkanmuOlapade R Ilesanmi
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Mar 2, 2010·TheScientificWorldJournal·Natalie L RasgonAlan F Schatzberg
Apr 21, 2012·Diabetology & Metabolic Syndrome·R JayawardenaP Katulanda
May 17, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·S BybergD R Witte
Jun 2, 2012·Patient Preference and Adherence·Khalid Saad Al-Harbi
Nov 10, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Jasmine CapdorSamir Samman
May 9, 2013·Nature Medicine·Maryam AhmadianRonald M Evans
Nov 8, 2013·The American Journal of Clinical Nutrition·Jun S LaiJohn Attia
Dec 10, 2013·Journal of Affective Disorders·Roger S McIntyreMaia Miguelez
Mar 19, 2014·Annals of the New York Academy of Sciences·Sirimon Reutrakul, Eve Van Cauter
Apr 12, 2014·BMC Psychiatry·Jerome SarrisMichael Berk
Apr 24, 2014·Oxidative Medicine and Cellular Longevity·Giuseppe GrossoFilippo Caraci
May 13, 2014·Annals of Medicine·Antti-Jussi PyykkönenKatri Räikkönen
May 13, 2014·Current Diabetes Reports·Christopher M DepnerKenneth P Wright
Jun 12, 2014·Nature Reviews. Neuroscience·Tara A LeGatesSamer Hattar
Sep 6, 2014·Nutrients·Elena García-FernándezAnna Bach-Faig
Nov 25, 2014·BMC Medical Research Methodology·Janus Christian JakobsenChristian Gluud
Dec 24, 2014·Journal of Affective Disorders·Mark A FryeSusannah J Tye
Dec 24, 2014·Journal of Affective Disorders·Shefali MillerTerence A Ketter
Jan 17, 2015·Indian Journal of Endocrinology and Metabolism·Manish GutchAbhinav Gupta
Jan 30, 2015·The British Journal of Nutrition·Carl J HulstonMichelle C Venables
Apr 9, 2015·Drugs·Katherine SemenkovichPatrick J Lustman
Sep 12, 2015·The Lancet. Psychiatry·Jerome SarrisUNKNOWN International Society for Nutritional Psychiatry Research
Sep 29, 2015·Current Neuropharmacology·Katarzyna Mlyniec
Sep 30, 2015·Lipids in Health and Disease·Barry Sears, Mary Perry
Nov 26, 2015·Psychiatry Research·Kathleen Watson LinNatalie L Rasgon
Apr 23, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Brian HallahanJohn M Davis
Apr 28, 2016·The Proceedings of the Nutrition Society·Margriet S Westerterp-Plantenga

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