Evaluation of the Effect of Intracoronary Attenuation on Coronary Plaque Measurements Using a Dual-phase Coronary CT Angiography Technique on a 320-row CT Scanner--In Vivo Validation Study

Academic Radiology
Masafumi KidohYasuyuki Yamashita

Abstract

The characterization of plaques based on their computed tomography (CT) number is important for the detection of vulnerable atherosclerotic plaques. An earlier in vitro study showed that intravascular attenuation affected the attenuation of coronary atherosclerotic plaques. We attempted to validate this finding in vivo and here we introduce a dual-phase coronary CT angiography (CCTA) technique to address this issue. Institutional ethics committee approval and informed consent were obtained. Thirty patients (30 noncalcified plaques) underwent dual-phase CCTA. Two CT datasets were obtained, one with coronary artery enhancement and the other without coronary artery enhancement. The CT number of the plaque and the adjacent vessel lumen was measured in a circular region of interest on curved planar reconstruction images. The region of interest setting was consistent between the two CT datasets. We performed linear regression analysis of the changes in the CT numbers (ΔHounsfield unit), calculated by subtracting the two CT datasets, for the lumen and for the plaque. We also evaluated the relationship between plaque attenuation on nonenhanced coronary artery images and luminal attenuation with and without contrast enhancement. The ΔHo...Continue Reading

References

Feb 24, 1999·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·K A JessenG Tosi
Sep 8, 2010·The International Journal of Cardiovascular Imaging·Maiken Glud DalagerHans Erik Bøtker
Feb 22, 2011·The International Journal of Cardiovascular Imaging·Arash BedayatRichard T Mather
Nov 9, 2011·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Aart J Van der MolenJacob Geleijns
Feb 7, 2012·Cardiology Clinics·Kunihiro YoshiokaKenta Muranaka
Oct 26, 2013·The International Journal of Cardiovascular Imaging·Ryoichi TanakaShigeru Ehara
Nov 15, 2013·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Yoshinori FunamaYasuyuki Yamashita
Feb 28, 2015·The International Journal of Cardiovascular Imaging·Kunihiro YoshiokaTsuyoshi Sugawara
Jun 21, 2015·Journal of Cardiovascular Computed Tomography·Andreas FuchsKlaus F Kofoed
Aug 21, 2015·The International Journal of Cardiovascular Imaging·Makoto AmanumaShinichi Takase

❮ Previous
Next ❯

Citations

Oct 12, 2018·BioMed Research International·Patrizia CaritàGianluca Pontone
Jul 22, 2018·The International Journal of Cardiovascular Imaging·Masafumi KidohYasuyuki Yamashita

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.