Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression

Progress in Neuro-psychopharmacology & Biological Psychiatry
Katarzyna GłombikAgnieszka Basta-Kaim

Abstract

Several lines of evidence indicate that adverse experience in early life may be a triggering factor for disturbances in the brain mitochondrial proteins and lead to the development of depression in adulthood. On the other hand, little is known about the impact of chronic administration of various antidepressant drugs on the brain mitochondria, as a target for the pharmacotherapy of depression. The purpose of our study was to compare the impact of chronic treatment with two antidepressant drugs with different mechanisms of action, a tricyclic antidepressant (TCA), imipramine, and an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class, fluoxetine, on the mitochondria-enriched subproteome profile in the hippocampus of 3-month-old male rats following a prenatal stress procedure (an animal model of depression). We clearly confirmed that chronic imipramine and fluoxetine administration not only normalized depression-like disturbances evoked by the prenatal stress procedure but also modulated the mitochondria-enriched subproteome profile in the hippocampus of adult offspring rats. In line with this, two-dimensional electrophoresis coupled with mass spectrometry showed a statistically significant down-regulation o...Continue Reading

Citations

Dec 12, 2018·The International Journal of Neuropsychopharmacology·Cristóbal Gómez-MolinaUrsula Wyneken
Feb 28, 2019·Cell Biology International·Zhiying HuMarong Fang
Nov 16, 2019·Current Neuropharmacology·Katarzyna ChameraAgnieszka Basta-Kaim
Jan 29, 2019·Early Intervention in Psychiatry·Oliver D RobertsonSeetal Dodd
Nov 30, 2019·Neurotoxicity Research·Katarzyna GłombikBogusława Budziszewska
Jun 22, 2018·Frontiers in Neuroscience·Josh AllenLisa E Kalynchuk
Jan 28, 2021·Antioxidants & Redox Signaling·Rachel SchroederHanna E Stevens
Sep 27, 2020·Molecular and Cellular Neurosciences·Virginie RappeneauChadi Touma
Nov 21, 2019·Schizophrenia Research·Shawna T ChanMarquis P Vawter
Mar 14, 2020·Pharmacology & Therapeutics·Andrea Carlo RossettiRaffaella Molteni
Mar 27, 2021·Mitochondrion·Katarzyna GłombikAgnieszka Basta-Kaim
Jul 3, 2021·Pharmaceutics·Olja MijanovicAndrey A Zamyatnin

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