Evaluation of the Effectiveness of Treatment with Dexamethasone Intravitreal Implant in Cystoid Macular Edema Secondary to Retinal Vein Occlusion

BioMed Research International
Simone DonatiClaudio Azzolini

Abstract

To evaluate retinal functional improvement by means of visual acuity and retinal sensibility examination after intravitreal dexamethasone implant in patients affected by cystoid macular edema secondary to retinal vein occlusion. Twenty-six consecutive patients affected by retinal vein occlusion complicated by cystoid macular edema were enrolled in this prospective interventional study. All patients underwent a baseline complete ophthalmological evaluation as well as retinal angiography, OCT examination, and microperimetry evaluation. Each patient was treated with intravitreal injection of a long-term steroid implant (Ozurdex, Allergan). Follow-up evaluations were performed at months 1, 3, and 6 and completed by OCT and MP1 examination. Clinical data underwent statistical analysis. Baseline functional evaluation showed mean visual acuity of 0,63±0,42 LogMAR and retinal sensitivity of 7,93±4,73 dB (mean±standard deviation); after treatment, at day 30 we found, respectively, 0,43±0,38 LogMAR (p<0.05, compared to baseline) and 10,15±4,410 dB (p<0.05); at day 90, we found 0,44±0,32 (p<0.05) and 9.61±4,29 dB (p<0.05); at day 180, we found 0,41±0,31 (p<0.05) and 9,95±3,79 dB (p<0.05). Fixation pattern improved significantly (p<0.05), ...Continue Reading

Associated Clinical Trials

References

Jun 27, 2006·Investigative Ophthalmology & Visual Science·Stela VujosevicFabiano Cavarzeran
Mar 14, 2007·Archives of Ophthalmology·Baruch D KuppermannUNKNOWN Dexamethasone DDS Phase II Study Group
Aug 30, 2008·Progress in Retinal and Eye Research·Klaus RohrschneiderChristina Springer
Jun 5, 2010·Ophthalmology·Neil M Bressler, Andrew P Schachat
May 18, 2011·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Gabriel CoscasGiovanni Staurenghi
May 24, 2011·Survey of Ophthalmology·Justis P Ehlers, Sharon Fekrat
Jul 3, 2013·European Journal of Ophthalmology·Claudio AzzoliniGianni Virgili
Jun 14, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Giuseppe QuerquesFrancesco Bandello
Jan 13, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sibylle WinterhalterAntonia M Joussen
Mar 7, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hongting LiuQuan Dong Nguyen
May 15, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Justus G Garweg, Souska Zandi
Oct 8, 2016·Seminars in Ophthalmology·Simone DonatiClaudio Azzolini

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Citations

May 18, 2019·Journal of Ophthalmology·Simone DonatiClaudio Azzolini
Feb 8, 2022·Investigative Ophthalmology & Visual Science·Francesco TestaFrancesca Simonelli

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