Evaluation of the effects of Angelicae dahuricae radix on the morphology and viability of mesenchymal stem cells

Molecular Medicine Reports
Su-Hyeon JeongJun-Beom Park

Abstract

Angelicae dahuricae radix is a traditional herbal medicine used to treat various diseases in China and Korea, such as colds, headaches, rhinitis and psoriasis. Angelicae dahuricae radix has been used as an anti-inflammatory, analgesic, antipyretic and antioxidant remedy. This study was performed in order to evaluate the effects of the extracts of Angelicae dahuricae radix on the morphology and viability of mesenchymal stem cells derived from the gingiva. Mesenchymal stem cells derived from the gingiva were grown in the presence of Angelicae dahuricae radix at final concentrations that ranged from 0.001 to 100 µg/ml. The morphology of the cells was viewed under an inverted microscope, and the analysis of cell proliferation was performed with cell counting kit-8 (CCK-8) on days 1, 3 and 7. The cells in the control group had spindle-shaped, fibroblast-like morphology at days 1, 3 and 7 under optical microscopy. The shapes of the cells in 0.001, 0.01, 0.1, 1, 10 and 100 µg/ml Angelicae dahuricae radix were similar to the shapes of the cells in the control group. The relative values of the CCK-8 assays of 0.001, 0.01, 0.1, 1, 10, and 100 µg/ml Angelicae dahuricae radix were 102.5 ± 0.6, 133.3 ± 9.6, 148.4 ± 20.5, 147.7 ± 12.6, 132.3...Continue Reading

References

Jan 14, 2005·Archives of Pharmacal Research·Pham Ngoc ThanhSam Sik Kang
Aug 16, 2013·Stem Cells and Development·Benjamin P J FournierLari Häkkinen

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Citations

Jun 18, 2016·Stem Cells International·Karim M Fawzy El-Sayed, Christof E Dörfer
Jul 22, 2017·Journal of Medicinal Food·Jingbo SunChunmei Wang
Aug 16, 2016·Stem Cell Research & Therapy·Vindya Lankika UdalamaththaPreethi Vidya Udagama
Dec 30, 2017·Experimental and Therapeutic Medicine·Hyunjin LeeJun-Beom Park

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