Evaluation of the effects of anti-motion sickness drugs on subjective sleepiness and cognitive performance of healthy males

Journal of Psychopharmacology
Aurélie WeertsFloris L Wuyts

Abstract

This study aimed to investigate the clinical and cognitive side effects of baclofen (10 mg), meclizine (25 mg), dimenhydrinate (40 mg) plus cinnarizine (25 mg) and promethazine (25 mg) plus d-amphetamine (10 mg). The study had a double-blind, placebo controlled, repeated measures design and was conducted on healthy male volunteers. The psychomotor vigilance test, the Sternberg working memory task, the implicit memory test and the automated Operation Span (Ospan) task were performed. The Stanford, the Karolinska and the Epworth Sleepiness scale determined the degree of sleepiness. The Profile of Mood States (POMS) evaluated mood states and adverse effects were reported on a 22-item questionnaire. Letter recalls and time for solving mathematical problems, recorded during the Ospan task, were impaired by baclofen and dimenhydrinate-cinnarizine respectively, suggesting an influence of these drugs on the working memory. Significant side effects for baclofen were: sleepiness, tiredness, blurred vision, concentration problems and dizziness whereas for dimenhydrinate-cinnarizine only sleepiness and blurred vision were reported. Meclizine decreased the accuracy on the Sternberg working memory task and thus seemed to affect short-term me...Continue Reading

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Citations

Apr 11, 2019·Journal of Medical Primatology·Lisa M Wooldridge, Brian D Kangas
Jun 4, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·R TeggiM Bussi
Mar 10, 2016·Chinese Journal of Integrative Medicine·Shi-Jun YangDa-Yong Cai
Oct 11, 2015·CNS Neuroscience & Therapeutics·Li-Li ZhangYi-Ling Cai
Apr 26, 2017·Journal of the Association for Research in Otolaryngology : JARO·Ana Diaz-ArtilesFaisal Karmali
Oct 30, 2020·Frontiers in Neurology·Vasilios M PolymeropoulosMihael H Polymeropoulos
Nov 7, 2020·Journal of Psychiatric Research·Anees BahjiLouise Good

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Methods Mentioned

BETA
sedation

Software Mentioned

SPSS
SPIN
UNIANOVA

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