Jan 14, 2016

Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis

Clinical Rheumatology
Dragan VasiljevicVladimir Jakovljevic


Rheumatoid arthritis is a chronic inflammatory disease. Reactive oxygen species have been considered as aggravating factors for autoimmune diseases. Fatty acids had been linked in reduction of various diseases by augment of their antioxidant potential and antiinflammatory mechanisms. The aim of this study was to assess the oxidative status in patients with rheumatoid arthritis who used concentrated fish oil only or concentrated fish oil in combination with evening primrose oil in a period of 3 months. Subjects were divided into three groups. The group I consists of patients who had been taking only their regular rheumatologic therapy; group II, patients who had been taking concentrated fish oil; and group III, patients who had been taking concentrated fish oil and evening primrose oil. Peripheral blood samples were used for all the assays. We assessed the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid-reactive substances (TBARS)), hydrogen peroxide (H2O2), superoxide anion radical (O2 (-)), nitric oxide (NO), superoxide dismutase activity (SOD), catalase activity (CAT), and glutathione levels (GSH) in erythrocytes. There were no statistically significant changes for any of the oxidative str...Continue Reading

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Mentioned in this Paper

Biological Markers
Thiobarbituric Acid Reactive Substances
Fish Liver Oils
Hydrogen Peroxide
Oenothera biennis
Chronic Inflammatory Disorder
Enzymes, antithrombotic
Peripheral Blood
Research Subject

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