Evaluation of the efficacy and safety of topical imiquimod 5% for plaque-type morphea: a multicenter, prospective, vehicle-controlled trial

Journal of Cutaneous Medicine and Surgery
Marlene DytocLoretta Fiorillo

Abstract

There is currently a lack of evidence-based therapies that are safe and effective for plaque-type morphea. We aimed to evaluate the therapeutic potential and safety profile of imiquimod 5% cream in plaque-type morphea. We enrolled 25 adult patients from two Canadian centers with histologically confirmed plaque-type morphea. Imiquimod 5% was applied to a representative plaque, and vehicle was applied to a control plaque for 9 months. Treatment efficacy was assessed with the Dyspigmentation, Induration, Erythema, and Telangiectasias (DIET) score, histology, and ultrasound evaluation. Twenty-two patients completed the entire length of the study. Imiquimod 5% was superior to vehicle in reducing DIET scores at 3, 6, 9, and 12 months (p < .05). Induration demonstrated the greatest response. Histologic evaluation showed significant improvement or resolution of disease. However, no ultrasonographic differences were found in dermal and hypodermal thicknesses between the treatment and vehicle groups (p > .05). Adverse effects were minimal and well tolerated.

References

Mar 1, 1997·Journal of the American Academy of Dermatology·N HunzelmannT Krieg
May 20, 2003·The British Journal of Dermatology·A CosnesC Radier
Sep 27, 2005·The British Journal of Dermatology·M DytocL Fiorillo
Jun 1, 2007·Dermatologic Therapy·Heidi T JacobePaul R Bergstresser
Jul 17, 2009·Current Rheumatology Reports·Suzanne C Li, Melissa S Liebling
Oct 17, 2009·The Journal of Rheumatology·Thaschawee ArkachaisriUNKNOWN Localized Scleroderma Clinical and Ultrasound Study Group
Jan 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L RankinStefan Pflanz
Apr 29, 2010·Pediatric Rheumatology Online Journal·Suzanne C LiAndrea S Doria
Jan 18, 2011·Journal of the American Academy of Dermatology·Nicole Fett, Victoria P Werth
Jun 8, 2011·Journal of the American Academy of Dermatology·Brittany A Zwischenberger, Heidi T Jacobe
Feb 14, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·Elena PopeRonald M Laxer
Mar 17, 2012·Indian Journal of Dermatology, Venereology and Leprology·Nicole M Fett

❮ Previous
Next ❯

Citations

Jul 13, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A Lis-ŚwiętyL Brzezińska-Wcisło
Mar 18, 2017·American Journal of Clinical Dermatology·Jorre S MertensElke M G J de Jong
Jul 17, 2019·The Cochrane Database of Systematic Reviews·Julia V de AlbuquerqueVirginia Fm Trevisani
Jun 28, 2020·Current Rheumatology Reports·Francesco Zulian, Francesca Tirelli

❮ Previous
Next ❯

Methods Mentioned

BETA
targeted mutations
biopsies
Biopsy

Software Mentioned

GraphPad Prism
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.