Evaluation of the efficacy and safety of tavaborole topical solution, 5%, in the treatment of onychomycosis of the toenail in adults: a pooled analysis of an 8-week, post-study follow-up from two randomized phase 3 studies

The Journal of Dermatological Treatment
A K GuptaP A Rich

Abstract

The role of topical antifungal agents in the long-term management of toenail onychomycosis is not well established. The current study evaluated durability of clinical benefit of tavaborole topical solution, 5%, for the treatment of toenail onychomycosis. We conducted a pooled analysis of 8-week, post-study follow-up (PSFU) data from two phase 3, randomized controlled trials in a subset of patients who experienced complete or almost clear nail (CN) at the end of treatment (week 52); 48 weeks of treatment with once-daily tavaborole compared with placebo in adults with distal subungual onychomycosis was evaluated at week 60. Complete cure (completely CN plus negative mycology) of the target great toenail and treatment success (<10% nail involvement plus negative mycology) were evaluated at week 52 versus week 60. Of the 62 patients who completed the PSFU, complete cure was higher in the tavaborole-treated group versus the vehicle control group (28.6% vs. 7.7%). Additionally, treatment success was 53.1% for the tavaborole group versus 23.1% in the vehicle group. Small sample size entering the PSFU limited robust statistical analysis. Tavaborole topical solution, 5%, appears to provide durable clinical benefit, making it an attracti...Continue Reading

References

Apr 1, 1994·The British Journal of Dermatology·R K Scher
May 20, 1998·Journal of the American Academy of Dermatology·L A DrakeM J Stiller
Sep 3, 1999·Drugs·M Niewerth, H C Korting
Mar 24, 2000·The British Journal of Dermatology·C De Cuyper, P H Hindryckx
Nov 28, 2001·American Journal of Clinical Dermatology·J E ArreseG E Piérard
Oct 23, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Jorge E Arrese, Gérald E Piérard
Apr 21, 2004·Journal of the American Academy of Dermatology·K Wade FosterBoni E Elewski
Jun 10, 2004·American Journal of Clinical Dermatology·W Philip WerschlerDavid Armstrong
Feb 1, 2006·The British Journal of Dermatology·K SardanaM Rajpal
Jul 11, 2007·Journal of Pharmaceutical Sciences·Xiaoying HuiHoward I Maibach
Sep 14, 2010·Journal of Clinical Pharmacy and Therapeutics·J ThomasC Sharpe
Feb 19, 2014·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Pietro NenoffHans-Jürgen Tietz
Feb 26, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Annika SarnesLeena Peltonen
May 27, 2014·Expert Opinion on Pharmacotherapy·Boni E Elewski, Antonella Tosti
Jul 19, 2014·Journal of Psychiatric Practice·David McMahon, Sheldon H Preskorn
Oct 3, 2015·Journal of the American Podiatric Medical Association·Bryan Markinson, Bryan Caldwell

❮ Previous
Next ❯

Citations

Nov 10, 2018·Expert Review of Anti-infective Therapy·Aditya K GuptaVincent Piguet
Jan 25, 2020·The Cochrane Database of Systematic Reviews·Kelly FoleyDenny John
Nov 19, 2019·Recent Patents on Inflammation & Allergy Drug Discovery·Alexander K C LeungAlex H C Wong
Jul 3, 2020·Journal of Cosmetic Dermatology·Aditya K Gupta, Emma M Quinlan
Sep 30, 2020·Expert Opinion on Drug Safety·Jose W Ricardo, Shari R Lipner
Jul 13, 2019·F1000Research·Aditya K Gupta, Nadia Stec
Feb 2, 2019·American Journal of Clinical Dermatology·Partik Singh, Jonathan I Silverberg
Nov 21, 2018·American Journal of Clinical Dermatology·Aditya K GuptaBianca Maria Piraccini
Jan 17, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Elizabeth Estevez-FregosoMarvin A Soriano-Ursúa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.