Evaluation of the efficacy of hyperbaric oxygen therapy in the management of chronic nonhealing ulcer and role of periwound transcutaneous oximetry as a predictor of wound healing response: A randomized prospective controlled trial.

Journal of Anaesthesiology, Clinical Pharmacology
Sarbjot KaurRakesh Garg

Abstract

Hyperbaric oxygen therapy (HBOT) is a treatment option for chronic nonhealing wounds. Transcutaneous oximetry (TCOM) is used for wound assessment. We undertook a randomized prospective controlled trial to evaluate the role of HBOT in healing of chronic nonhealing wounds and to determine whether TCOM predicts healing. This study was conducted in 30 consenting patients with nonhealing ulcer. The patients were randomized into group HT (receiving HBOT in addition to conventional treatment) and group CT (receiving only conventional treatment). Duration of treatment in both the groups was 30 days. Wound ulcer was analyzed based on size of the wound, exudates, presence of granulation tissue, and wound tissue scoring. Tissue oxygenation (TcPO(2)) was measured on 0, 10(th), 20(th), and 30(th) day. There was 59% reduction in wound area in group HT and 26% increase in wound area in group CT. Ten patients in group HT showed improvement in wound score as compared to five patients in group CT. Complete healing was seen in three patients in group HT as compared to none in group CT. Surgical debridement was required in 6 patients in group HT and 10 patients in group CT. One patient in group HT required amputation as compared to five patients i...Continue Reading

References

Jul 1, 1991·Clinical Physiology·F G Quigley, I B Faris
Jan 1, 1987·Diabetes Care·G BaroniF Favales
Jun 1, 2002·Journal of Diabetes and Its Complications·Majid KalaniKerstin Brismar
Aug 23, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Caroline E FifeJon Mader
Nov 18, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Juha Niinikoski
Feb 13, 2004·World Journal of Surgery·Juha H A Niinikoski
Jun 23, 2004·QJM : Monthly Journal of the Association of Physicians·A L Gill, C N A Bell
Jul 25, 2009·PM & R : the Journal of Injury, Function, and Rehabilitation·Robert J Goldman
Apr 30, 2010·Diabetes Care·Benjamin A Lipsky, Anthony R Berendt
Dec 25, 2010·World Journal of Surgery·Anne M EskesHester Vermeulen

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Citations

Dec 24, 2015·Oxidative Medicine and Cellular Longevity·Pedro González-MuniesaJ Alfredo Martinez
Oct 19, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alexandra C KendallPaul Eggleton
Jul 5, 2012·Annals of the New York Academy of Sciences·Giuseppe ValacchiValter Travagli
Jun 8, 2013·Dermatologic Therapy·Lee J Goldstein
Aug 8, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Gijs H J de SmetJohan F Lange
Oct 3, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maciej M KmiecPeriannan Kuppusamy
Oct 10, 2019·International Wound Journal·Laura Bolton
Jun 25, 2015·The Cochrane Database of Systematic Reviews·Peter KrankeStephanie Weibel
Sep 17, 2014·Advances in Skin & Wound Care·Gregory Ralph WeirR Gary Sibbald
Aug 14, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Pasquale LongobardiAntonio L'Abbate
Jul 6, 2019·BioMed Research International·Chen-Yu ChenRe-Wen Wu
Jan 5, 2021·The International Journal of Lower Extremity Wounds·Jarosław PasekGrzegorz Cieślar
Jun 30, 2021·Diabetes & Metabolic Syndrome·Ethar Mohamedalfatih FadolIman Hassan Abdoon
Jul 6, 2021·Frontiers in Cell and Developmental Biology·Christian Johann LercheClaus Moser

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Methods Mentioned

BETA
X-ray
amputation

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