Evaluation of the efficacy of tranexamic acid on blood loss in orthognathic surgery. A prospective, randomized clinical study

International Journal of Oral and Maxillofacial Surgery
Duraiswamy SankarB Vikraman

Abstract

The purpose of this prospective, randomized, double blind study was to assess the effect of tranexamic acid on blood loss, quality of surgical field and duration of surgery in adolescent orthognathic surgery patients. 50 consecutive patients, scheduled for orthognathic surgery were included. The study group (n=25) received tranexamic acid 10mg/kg as a bolus preoperatively followed by 1mg/kg as a maintenance dose intra operatively; the control group (n=25) received placebo (normal saline). All patients received moderate hypotensive anaesthesia with nitroglycerin and had surgery according to a standard protocol. Intra operative blood loss, duration of surgery, quality of surgical field, blood transfusion and complications, if any, were recorded. The mean total blood loss was 166.1±65.49ml in the study group and 256.4±77.80ml in the control group. The results showed statistically significant reduction in blood loss (p<0.001) and improved quality of surgical field (p<0.001) in the study group. There was no significant difference in duration of surgery and transfusion requirements between the two groups. In conclusion, preoperative and intra operative administration of the antifibrinolytic agent, tranexamic acid, is effective in con...Continue Reading

References

Dec 1, 1976·International Journal of Oral Surgery·N Gersel-Pedersin
Oct 1, 1990·The British Journal of Oral & Maxillofacial Surgery·T R FloodA el-Attar
Jun 1, 1986·Anesthesia and Analgesia·G A FrommeK P Offord
Jun 28, 1968·Annals of the New York Academy of Sciences·L AnderssonB Melander
Feb 1, 1995·Anesthesiology·J C HorrowJ L Parmet
Jun 1, 1996·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·D S PreciousD Bosco
Aug 2, 2002·Anesthesiology·Noreen P DowdJohn Butterworth
Jun 1, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Göran ZellinK-E Kahnberg
Dec 17, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Wing Shan ChoiNabil Samman

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Citations

Dec 3, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Hamidreza EftekharianReza Tabrizi
Jun 16, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jesper J OlsenElse M Pinholt
Oct 12, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Vikram Shetty, Ganapathy Sriram S
Apr 30, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Amelia ChristabelNavaneetha Krishnan
Dec 25, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Guodong SongQiushi Wang
Oct 11, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yu-Chuan TsengChun-Ming Chen
Mar 21, 2017·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Guilherme C ArantesMaria do Carmo M B Duarte
Dec 18, 2015·The Journal of Craniofacial Surgery·Hamid Reza Eftekharian, Zahra Rajabzadeh
Nov 2, 2017·Journal of Dental Anesthesia and Pain Medicine·So-Young ParkMyong-Hwan Karm
May 26, 2018·Plastic and Reconstructive Surgery·Stav BrownPeter J Taub
Mar 12, 2016·The Journal of Craniofacial Surgery·George Richard Francis MurphyAbhilash Jain
Oct 10, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Kazem KhiabaniSahand Samieirad
Mar 5, 2021·Facial Plastic Surgery & Aesthetic Medicine·Rao FuRu-Lin Huang

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