Evaluation of the Elecsys(®) Anti-HCV II assay for routine hepatitis C virus screening of different Asian Pacific populations and detection of early infection

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Soo Jin YooLai Wei

Abstract

Early diagnosis of hepatitis C virus (HCV) infection is essential to allow appropriate treatment and prevent transmission. To evaluate the Elecsys(®) Anti-HCV II assay as a routine screening assay in Asia using a large number of samples from different Asian Pacific populations and compare its performance with other HCV assays routinely used in the region. The sensitivity and specificity of the Elecsys(®) Anti-HCV II assay were determined using routine hospital samples and compared with at least one of the following comparator assays at nine independent centers: ARCHITECT™ Anti-HCV; Serodia(®)-HCV Particle Agglutination; Vitros(®) ECi Anti-HCV; Elecsys(®) Anti-HCV; ADVIA Centaur(®) HCV; InTec(®) HCV EIA; or Livzon(®) Anti-HCV. Commercially available seroconversion panels were used to assess sensitivity for early detection of infection. The Elecsys(®) Anti-HCV II assay was more sensitive in recognizing early infection and detected acute HCV infection earlier on average than the comparator assays for all six panels tested. 7,726 routine samples were tested and 322 identified as HCV positive. Elecsys(®) Anti-HCV II had a sensitivity of 100% and a specificity of 99.66%, both of which were comparable or superior to the results obtain...Continue Reading

References

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Citations

Dec 17, 2015·Journal of Clinical Laboratory Analysis·Dongdong LiChuanmin Tao
Sep 9, 2017·Archives of Virology·Robério Amorim de Almeida Pondé
Mar 5, 2019·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Maeesa Wadood, Muhammad Usman
Nov 17, 2017·BMC Infectious Diseases·Weiming TangPhilippa Easterbrook
Jul 18, 2021·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Youn Keong ChoYounhee Park

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