Evaluation of the epidermal refractive index measured by optical coherence tomography

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Michael SandKlaus Hoffmann

Abstract

It has recently been proposed that the refractive index (RI) measured by means of optical coherence tomography (OCT) may be a valid measure for hydration of skin. In this pilot study, using OCT in vivo, we aimed to investigate the interday variability of RI measurements and acute changes of RI following the application of a moisturizer. Twenty healthy Caucasian volunteers were investigated on their forearms using a commercially available OCT system (SkinDex 300, ISIS optronics GmbH, Mannheim, Germany) fitted with an integrated algorithm for the evaluation of the RI. The interday repeatability of the OCT method was determined performing symmetrical measurements on both forearms on day 1, 5, 9, and 13. In order to investigate the acute effect of a moisturizer on RI, OCT assessments were performed before and 10 min after the application of an aqueous lotion with a lipophilic phase. As a control, the contralateral site was investigated in the same way, except for the use of distilled water instead of the lotion. Assessments of interday variability revealed insignificant (P>0.05) variances between the four measurement times as expressed in very small repeatability coefficients (right arm: 0.039; left arm 0.053) and small coefficient...Continue Reading

References

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Citations

Jun 8, 2011·Archives of Dermatological Research·Thilo GambichlerSarah Terras
Nov 25, 2011·Journal of Biomedical Optics·Shikhar UttamYang Liu
May 26, 2007·Journal of Cosmetic Dermatology·Sylvie Verdier-Sévrain, Frédéric Bonté
Jan 10, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Robert K MlosekAnna Dąbrowska
Mar 19, 2014·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Tetsuya Tsugita, Toshiaki Iwai
Jul 1, 2010·Optics Express·Chien-Kun Ting, Yin Chang
Jun 27, 2009·Journal of Biophotonics·Mette MogensenGregor B E Jemec
Oct 1, 2019·Biomedical Optics Express·Yarden Tzabari KelmanZeev Zalevsky
Jan 29, 2021·Photodiagnosis and Photodynamic Therapy·Rana KhanIftikhar Ahmad
Oct 27, 2021·Photochemistry and Photobiology·Louise FinlaysonKenneth Wood

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