Evaluation of the estrogenic potential of river and treated waters in the Paris area (France) using in vivo and in vitro assays

Ecotoxicology and Environmental Safety
Maëlle CargouëtYves Levi

Abstract

For many years, surface waters have been shown to be contaminated by endocrine-disrupting compounds (EDCs), which can cause adverse effects on human and wildlife growth, development, and reproduction. It is therefore of primary importance to determine if drinking water could be contaminated by EDCs when produced from polluted surface waters. It is also essential to determine if disinfection by-products can account for estrogenic activity in treated waters. The estrogenic potential of river and treated waters was investigated using an in vivo assay. Adult male zebrafish were placed in three drinking water treatment plants (DWTPs) in the Paris area and exposed for 1 month to the two types of waters. After exposure, vitellogenin (VTG) was measured in the plasma of fish using a competitive ELISA. In addition, an in vitro assay (MELN cells) was used to assess the estrogenic potential of 10 major chlorination by-products. No significant induction of VTG was observed in fish exposed to river or treated waters. Among the 10 chlorination by-products tested, only 2-chlorophenol was found to be weakly estrogenic at concentrations up to 1mg/L. Therefore, the risk for the three DWTPs studied to produce drinking water with significant level ...Continue Reading

References

Mar 1, 1993·Archives of Environmental Health·A AschengrauA Cohen
Oct 1, 1995·Environmental Health Perspectives·J P Sumpter, S Jobling
May 7, 1999·Environmental Health Perspectives·G A Boorman
Sep 7, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·H HolbechP Bjerregaard
May 10, 2002·Chemosphere·Dang Quang Hung, Wolfram Thiemann
Aug 21, 2003·Ecotoxicology and Environmental Safety·K Van den BeltH Witters
Apr 15, 2004·The Science of the Total Environment·Maëlle CargouëtYves Levi

❮ Previous
Next ❯

Citations

Jul 18, 2009·Environmental Monitoring and Assessment·Meei-Fang ShueTing-Chien Chen
Mar 23, 2010·The Science of the Total Environment·Sonia DagninoHélène Fenet
Aug 13, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tiziana SchiliròGiorgio Gilli
May 3, 2011·Marine Pollution Bulletin·Angéline BertinRenato A Quiñones
Nov 2, 2011·Journal of Environmental Monitoring : JEM·Ana Marcela Di Dea BergamascoGisela de Aragão Umbuzeiro
May 1, 2013·Ecological Indicators·Tingting XuSteven Ripp

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.