Evaluation of the EYTEX(TM) system in the COLIPA eye irritation program

Toxicology in Vitro : an International Journal Published in Association with BIBRA
P CourtellemontB Breda

Abstract

In the context of the 6th Amendment of the European Directive on Cosmetics, several cosmetic companies concentrate their basic research on the development of the best adapted battery of in vitro tests able to be incorporated in the ocular risk assessment process. Consequently, the European Cosmetic Toiletry and Perfumery Association (COLIPA) has initiated an international multicentric study with the main purpose to validate available alternatives in vitro methods for assessing the eye irritation potential of cosmetic raw materials and formulations. The alternative methods assessed in this validation study were chosen since all of these tests had already been used and continue to be conducted in the risk assessment process. The different endpoints of these assays are mainly biological parameters except for the biochemical assay named EYTEX(TM). In this article, the defined prediction models and the different protocols used in the COLIPA study are described. Then, the EYTEX assay results are presented and discussed in details in order to understand the failure of this assay during this validation study. The relevance and the reliability of the EYTEX assay were particularly low in two laboratories, whereas one laboratory presented...Continue Reading

References

Jul 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·L H BrunerR D Parker
Dec 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M BallsH Spielmann
Aug 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L H BrunerR D Curren
Feb 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P G BrantomM Stern
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·O BleinK G Dossou

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Citations

Dec 3, 2014·Toxicology·Samantha L WilsonAndrew Hopkinson
Mar 19, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chantra EskesNathan Wilt
May 9, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Michalis G NikolaidisDimitris Kouretas
Dec 18, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Aristidis S VeskoukisDimitrios Kouretas
Dec 9, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·James ClarkBastiaan Hoogendoorn
Oct 18, 2018·American Journal of Physiology. Renal Physiology·Pauline ErpicumFrançois Jouret
Apr 27, 2005·Human & Experimental Toxicology·P MurugesanJ Arunakaran
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Agnès MaurelBernard Francés
Dec 17, 2008·Alternatives to Laboratory Animals : ATLA·Christina GrindonJohn F Garrod
Oct 1, 2005·Alternatives to Laboratory Animals : ATLA·Chantra EskesValérie Zuang
Dec 15, 2004·Alternatives to Laboratory Animals : ATLA·Ludwig A Hothorn
Mar 13, 2008·Alternatives to Laboratory Animals : ATLA·Christina GrindonJohn F Garrod

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