Evaluation of the Helicobacter pylori stool antigen test for monitoring eradication therapy

The American Journal of Gastroenterology
Takeo OdakaFumio Nomura

Abstract

We aimed to clarify the time course of the Helicobacter pylori stool antigen (HpSA) level during and after eradication therapy and to determine the appropriate time of measurement of HpSA to evaluate eradication. The subjects were 47 patients who were positive for H. pylori. The patients underwent a 1-wk regimen of triple therapy. The outcome of the eradication therapy was judged by urea breath test, culture, and histology 6 wk after the end of treatment. The HpSA level was serially measured nine times from before therapy until 12 wk after the end of therapy. In the group with successful eradication, HpSA became negative immediately after the end of therapy and the negativity persisted. In contrast, in the noneradication group HpSA became negative immediately after therapy, but became positive again within 2 wk after the end of therapy. The mean absorbance value of the HpSA test on the 4th day after the initiation of eradication therapy was significantly higher in the noneradication group than in the group with successful eradication. The diagnostic accuracy of the HpSA test increased to > or = 90% 2 wk after therapy and thereafter. Comparison of the diagnostic accuracy at 4 wk after the end of therapy showed no significant dif...Continue Reading

References

Jul 1, 1990·Clinical Microbiology Reviews·D M Ilstrup
Oct 4, 1995·JAMA : the Journal of the American Medical Association·B J Marshall
Aug 5, 1995·Lancet·I L BealesJ Calam
Jun 17, 1995·Lancet·E J KuipersS G Meuwissen
Jun 1, 1994·Gut·J C Atherton, R C Spiller
Feb 15, 2000·Scandinavian Journal of Gastroenterology·R OhkuraN Sato
Aug 5, 2000·The American Journal of Gastroenterology·N VakilS Phadnis
Dec 16, 2000·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M O HussonP S Ganga-Zandzou
Jan 10, 2001·Alimentary Pharmacology & Therapeutics·G OderdaA Zavallone

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Citations

Dec 24, 2013·World Journal of Gastroenterology : WJG·Tadashi Shimoyama
Aug 30, 2006·Annals of Medicine·Hannu M PaimelaPentti I Sipponen
Jul 24, 2004·Helicobacter·Javier P Gisbert, José María Pajares
Jun 6, 2003·Alimentary Pharmacology & Therapeutics·C BassetD Vaira
Jul 5, 2007·The American Journal of Gastroenterology·William D CheyUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Oct 24, 2002·Journal of Clinical Gastroenterology·John K Marshall, Deborah L R Yamamura
Feb 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Grazyna GościniakAleksander Blitek
May 20, 2003·Journal of Gastroenterology and Hepatology·Akifumi TanakaShin'ichi Takahashi
Dec 22, 2004·Helicobacter·Hwai-Jeng LinYueh-Hsing Ou
Jan 27, 2006·World Journal of Gastroenterology : WJG·Lea VeijolaHilpi Rautelin
Apr 14, 2020·BioMed Research International·Antone R OpekunFred M Sutton

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