Evaluation of the HER2 and Hormone Receptor Status in Metastatic Breast Cancer Using Cell Blocks: A Multi-Institutional Study

Acta Cytologica
Rieko NishimuraNatsumi Yamashita

Abstract

We explore the problems associated with the cell block (CB) method for receptor analysis in breast cancer metastases and propose a method for reporting the results. Nine institutions used the CB method for the analysis of hormone receptors (HRs) and HER2 (human epidermal growth factor receptor 2) protein in cytological specimens of breast cancer metastases in routine practice. The stained slides were independently evaluated by 8 pathologists. Dual in situ hybridization assay was performed in cases of discordant results for HER2 protein. Based on the results, we propose a method for receptor scoring in the CB method. Of 61 specimens, 57 contained tumor cells. Two or more pathologists disagreed on the results for the estrogen receptor, progesterone receptor, and HER2 protein in 3 (5.3%), 13 (22.8%), and 19 (33.3%) cases, respectively. The discrepant results for the HRs were attributed to the presence of a few positive cells or faintly stained cells. The high interobserver discordance rate for HER2 protein was explained by interobserver differences in the scoring criteria. The use of categorical scoring into positive and negative is recommended for evaluating the HR expressions. Use of strict criteria for HER2 protein 2+ and 3+ ca...Continue Reading

References

Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
Mar 8, 2011·Cytopathology : Official Journal of the British Society for Clinical Cytology·S K KumarG Singh
Nov 20, 2012·American Journal of Clinical Pathology·David A CohenRohit Bhargava
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Oct 28, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Rieko NishimuraNatsumi Yamashita

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Citations

May 23, 2019·Cancer Cytopathology·Raghavendra Pillappa, Adele O Kraft
Feb 6, 2020·Diagnostic Cytopathology·Ronald C K ChanAnthony W H Chan

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