Evaluation of the human IgG antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites.

PLoS Neglected Tropical Diseases
Souleymane DoucoureFranck Remoue

Abstract

The spread of Aedes albopictus, a vector for re-emergent arbovirus diseases like chikungunya and dengue, points up the need for better control strategies and new tools to evaluate transmission risk. Human antibody (Ab) responses to mosquito salivary proteins could represent a reliable biomarker for evaluating human-vector contact and the efficacy of control programs. We used ELISA tests to evaluate specific immunoglobulin G (IgG) responses to salivary gland extracts (SGE) in adults exposed to Aedes albopictus in Reunion Island. The percentage of immune responders (88%) and levels of anti-SGE IgG Abs were high in exposed individuals. At an individual level, our results indicate heterogeneity of the exposure to Aedes albopictus bites. In addition, low-level immune cross-reactivity between Aedes albopictus and Aedes aegypti SGEs was observed, mainly in the highest responders. Ab responses to saliva could be used as an immuno-epidemiological tool for evaluating exposure to Aedes albopictus bites. Combined with entomological and epidemiological methods, a "salivary" biomarker of exposure to Aedes albopictus could enhance surveillance of its spread and the risk of arbovirus transmission, and could be used as a direct tool for the eva...Continue Reading

References

Aug 1, 1994·International Archives of Allergy and Immunology·T ReunalaT Palosuo
Mar 1, 1994·The Journal of Allergy and Clinical Immunology·H Brummer-KorvenkontioT Palosuo
Sep 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Z PengF E Simons
Mar 1, 1997·Allergy·H Brummer-KorvenkontioT Reunala
Sep 20, 2001·The American Journal of Tropical Medicine and Hygiene·R J NascimentoA R Teixeira
Aug 27, 2002·Annual Review of Entomology·Jose M C Ribeiro, Ivo M B Francischetti
Oct 1, 2003·Tissue & Cell·Marcos M ReisMaurilio J Soares
Feb 14, 2004·International Archives of Allergy and Immunology·Zhikang Peng, F Estelle R Simons
Oct 11, 2005·The Journal of Experimental Biology·Bruno ArcàJosé M C Ribeiro
Nov 29, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Franck RemoueFrançois Simondon
Mar 15, 2006·Acta Tropica·Amornrat WaitayakulRachanee Udomsangpetch
Mar 18, 2006·Parasite Immunology·P F BillingsleyC Drakeley
Jan 25, 2007·Insect Biochemistry and Molecular Biology·Bruno ArcàJosé M C Ribeiro
Sep 11, 2007·Acta Tropica·Franck RemoueFrançois Simondon
Dec 7, 2007·Lancet·G RezzaUNKNOWN CHIKV study group
Mar 17, 2009·Cadernos de saúde pública·Héctor Gómez-Dantés, Janine Ramsey Willoquet
May 20, 2009·Microbes and Infection·C PaupyD Fontenille
Jul 11, 2009·Vector Borne and Zoonotic Diseases·Helene DelatteDidier Fontenille
Aug 12, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Erin StaplesAnn M Powers
Oct 28, 2009·Antiviral Research·Scott C Weaver, William K Reisen
Nov 3, 2009·Proteomics·Ladawan WasinpiyamongkolDorothée Missé
Dec 8, 2009·Journal of Medical Entomology·Leïla BagnyDidier Fontenille
Apr 23, 2010·Tropical Medicine & International Health : TM & IH·L SanchezP Van der Stuyft
Nov 3, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E A GouldR N Charrel

❮ Previous
Next ❯

Citations

May 24, 2014·PLoS Neglected Tropical Diseases·Guy CaljonJan Van Den Abbeele
Jan 11, 2013·Arthritis Research & Therapy·Patrick GérardinFrançois Favier
Nov 26, 2015·Insects·Souleymane Doucoure, Papa Makhtar Drame
Oct 19, 2012·Proteomics·Sirilaksana PatramoolDorothée Missé
Jun 4, 2015·Pest Management Science·Frédéric BaldacchinoAnnapaola Rizzoli
Jun 10, 2015·Journal of Infection and Public Health·Rike OktariantiAulanni'am
Dec 5, 2012·PLoS Neglected Tropical Diseases·Soumaya MarzoukiMélika Ben Ahmed
Dec 5, 2014·PLoS Neglected Tropical Diseases·Alexandra SchwarzJosé M C Ribeiro
Feb 7, 2015·PLoS Neglected Tropical Diseases·Guy CaljonJan Van Den Abbeele
Feb 14, 2017·Vector Borne and Zoonotic Diseases·Victoria Pando-Robles, Cesar V Batista
Jul 22, 2015·The American Journal of Tropical Medicine and Hygiene·Berlin Londono-RenteriaSteven R Meshnick
Sep 4, 2018·BioMed Research International·Céline Mabot YoboBenjamin Guibéhi Koudou
Aug 28, 2020·Frontiers in Cellular and Infection Microbiology·Sara Buezo MonteroBruno Arcà
May 30, 2013·Insect Molecular Biology·S DoucoureF Remoue
Oct 3, 2018·Tropical Medicine and Infectious Disease·André B SagnaFranck Remoue

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Graph Pad Prism

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.